Klein B E, Moss S E, Klein R, Magli Y L, Hoyer C H
Department of Ophthalmology, University of Wisconsin, Madison 53792.
Invest Ophthalmol Vis Sci. 1990 May;31(5):805-9.
Neuroretinal rim area (NRA) may indicate the amount of viable optic nerve tissue. Changes in the NRA have been found to occur in people with glaucoma. We sought to determine whether there were effects of retinopathy and intraocular pressure (IOP) on NRA in eyes of people with diabetes. Measurements of optic discs and cups were taken from 35-mm stereoscopic slides taken with a Zeiss fundus camera. The photographs were taken during a population-based study. The difference between disc and cup area was taken to be the NRA. Median photographic NRA from 2085 right eyes was 10.5 mm2. In younger- and older-onset persons, NRA showed a tendency to increase with age and, inconsistently, with the severity of diabetic retinopathy; it decreased with increasing IOP in older-onset persons not taking insulin. The cohort was reevaluated 4 yr later. NRA increased in all groups. Measurements from photographs taken of a nondiabetic comparison group showed no change over the same interval. These data suggest that NRA may be affected by diabetes. This could be due to nerve swelling.
神经视网膜边缘区域（NRA）可能表明存活视神经组织的数量。已发现青光眼患者的NRA会发生变化。我们试图确定视网膜病变和眼压（IOP）对糖尿病患者眼睛的NRA是否有影响。视盘和视杯的测量数据来自用蔡司眼底相机拍摄的35毫米立体幻灯片。这些照片是在一项基于人群的研究中拍摄的。视盘和视杯面积之差即为NRA。2085只右眼的摄影NRA中位数为10.5平方毫米。在早发型和晚发型患者中，NRA有随年龄增加而增加的趋势，且与糖尿病视网膜病变的严重程度变化不一致；在未使用胰岛素的晚发型患者中，NRA随眼压升高而降低。4年后对该队列进行了重新评估。所有组的NRA均增加。对非糖尿病对照组拍摄的照片进行的测量显示，在相同时间段内没有变化。这些数据表明NRA可能受糖尿病影响。这可能是由于神经肿胀所致。
