Klein B E, Moss S E, Magli Y L, Klein R, Hoyer C, Johnson J
Department of Ophthalmology, University of Wisconsin Medical School, Madison.
Invest Ophthalmol Vis Sci. 1989 Feb;30(2):310-5.
Change in optic disc cupping was evaluated in a 4-year follow-up of a well defined cohort of people with diabetes mellitus. Cup-to-disc ratios were computed for both vertical and horizontal diameters of each eye at the baseline and 4-year follow-up examinations. Graders were masked as to the identity of participants and to the dates of the photographs. Increases of at least 0.1 between baseline and follow-up were used as clinically significant change in the ratios. None of the following factors at baseline were consistent predictors of such a change: intraocular pressure, age, duration of diabetes, hypertension or severity of diabetic retinopathy. People who developed proliferative retinopathy by the follow-up examination were not more likely to have such an increase in ratio at the follow-up. We conclude that clinically significant increases in cup-to-disc ratio cannot be consistently predicted in people with diabetes from the risk factors evaluated with the grading system used in this study.
在一项针对明确的糖尿病患者队列的4年随访中，对视盘杯状凹陷的变化进行了评估。在基线检查和4年随访检查时，计算每只眼睛垂直和水平直径的杯盘比。分级人员对参与者的身份和照片日期均不知情。基线和随访之间杯盘比至少增加0.1被用作比值的临床显著变化。以下基线因素均不是这种变化的一致预测指标：眼压、年龄、糖尿病病程、高血压或糖尿病视网膜病变的严重程度。在随访检查时发生增殖性视网膜病变的人在随访时杯盘比增加的可能性并不更高。我们得出结论，根据本研究中使用的分级系统评估的危险因素，无法始终如一地预测糖尿病患者杯盘比的临床显著增加。
