Division of Inflammation, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
Nat Immunol. 2013 Mar;14(3):238-45. doi: 10.1038/ni.2525. Epub 2013 Jan 27.
Infection with influenza virus results in the deposition of anti-influenza CD8(+) resident memory T cells (T(RM) cells) in the lung. As a consequence of their location in the lung mucosal tissue, these cells are exposed to cytopathic pathogens over the life of the organism and may themselves be susceptible to infection. Here we found that lung T(RM) cells selectively maintained expression of the interferon-induced transmembrane protein IFITM3, a protein that confers broad resistance to viral infection. Lung T(RM) cells that lacked IFITM3 expression were more susceptible to infection than were their normal counterparts and were selectively lost during a secondary bout of infection. Thus, lung T(RM) cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures.
流感病毒感染会导致抗流感 CD8(+) 驻留记忆 T 细胞（T(RM) 细胞）在肺部沉积。由于它们位于肺部黏膜组织中，这些细胞在整个生命过程中都会暴露于细胞病变性病原体中，并且它们自身可能容易受到感染。在这里，我们发现肺 T(RM) 细胞选择性地维持干扰素诱导的跨膜蛋白 IFITM3 的表达，该蛋白赋予对病毒感染的广泛抗性。缺乏 IFITM3 表达的肺 T(RM) 细胞比正常对照细胞更容易感染，并且在二次感染时选择性地丢失。因此，肺 T(RM) 细胞被编程以保留 IFITM3 的表达，这有助于它们在随后的暴露中存活并免受病毒感染。
