人肿瘤组织中组织蛋白酶 K 免疫反应的广泛研究。
A broad survey of cathepsin K immunoreactivity in human neoplasms.
机构信息
Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD, USA.
出版信息
Am J Clin Pathol. 2013 Feb;139(2):151-9. doi: 10.1309/AJCPDTRTO2Z4UEXD.
Abstract
Cathepsin K is consistently and diffusely expressed in alveolar soft part sarcoma (ASPS) and a subset of translocation renal cell carcinomas (RCCs). However, cathepsin K expression in human neoplasms has not been systematically analyzed. We constructed tissue microarrays (TMA) from a wide variety of human neoplasms, and performed cathepsin K immunohistochemistry (IHC). Only 2.7% of 1,140 carcinomas from various sites exhibited cathepsin K labeling, thus suggesting that among carcinomas, cathepsin K labeling is highly specific for translocation RCC. In contrast to carcinomas, cathepsin K labeling was relatively common (54.6%) in the 414 mesenchymal lesions studied, including granular cell tumor, melanoma, and histiocytic lesions, but not paraganglioma, all of which are in the morphologic differential diagnosis of ASPS. Cathepsin K IHC can be helpful in distinguishing ASPS and translocation RCC from some but not all of the lesions in their differential diagnosis.
摘要
组织蛋白酶 K 在肺泡软组织肉瘤（ASPS）和部分易位型肾细胞癌（RCC）中始终呈弥漫性表达。然而，组织蛋白酶 K 在人类肿瘤中的表达尚未得到系统分析。我们从各种人类肿瘤中构建了组织微阵列（TMA），并进行了组织蛋白酶 K 免疫组织化学（IHC）检测。仅 1,140 例来自不同部位的癌中，有 2.7%显示组织蛋白酶 K 标记，因此表明在癌中，组织蛋白酶 K 标记对易位型 RCC 具有高度特异性。与癌相反，在研究的 414 种间叶性病变中，包括颗粒细胞瘤、黑色素瘤和组织细胞病变，但无副神经节瘤，组织蛋白酶 K 标记相对常见（54.6%），这些病变均在 ASPS 的形态学鉴别诊断范围内。组织蛋白酶 K IHC 有助于区分 ASPS 和易位型 RCC，以及它们鉴别诊断中的部分病变，但并非全部病变。
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