棕榈酰化依赖的谷氨酸受体及其 PDZ 结构域包含的伙伴的调节。
Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners.
机构信息
Shriners Hospital Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University Medical School, 3500 N. Broad Street, Philadelphia, PA 19130, USA.
出版信息
Biochem Soc Trans. 2013 Feb 1;41(1):72-8. doi: 10.1042/BST20120223.
Abstract
In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions. In the present paper, we review recent advances regarding the regulation of ionotropic glutamate receptor trafficking and function by palmitoylation.
摘要
近年来，人们已经清楚地认识到，AMPA（α-氨基-3-羟基-5-甲基异恶唑-4-丙酸）和 NMDA（N-甲基-D-天冬氨酸）型谷氨酸受体及其许多相互作用的伴侣都是棕榈酰化蛋白。干扰棕榈酰化作用会极大地影响受体的运输和分布，进而可以深刻改变突触传递。增加对突触棕榈酰化的了解不仅将有助于我们理解生理神经元调节，而且还可能为神经病理学状况提供见解，甚至提供新的治疗方法。在本文中，我们回顾了最近关于棕榈酰化调节离子型谷氨酸受体运输和功能的进展。
相似文献
1
Palmitoylation-dependent regulation of glutamate receptors and their PDZ domain-containing partners.棕榈酰化依赖的谷氨酸受体及其 PDZ 结构域包含的伙伴的调节。
Biochem Soc Trans. 2013 Feb 1;41(1):72-8. doi: 10.1042/BST20120223.
2
Palmitoylation-mediated synaptic regulation of AMPA receptor trafficking and function.棕榈酰化介导的 AMPA 受体转运和功能的突触调节。
Arch Pharm Res. 2019 May;42(5):426-435. doi: 10.1007/s12272-019-01134-z. Epub 2019 Mar 5.
3
S-palmitoylation regulates AMPA receptors trafficking and function: a novel insight into synaptic regulation and therapeutics.S-棕榈酰化调节α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体的转运与功能：对突触调节及治疗学的新见解
Acta Pharm Sin B. 2015 Jan;5(1):1-7. doi: 10.1016/j.apsb.2014.12.002. Epub 2014 Dec 29.
4
Post-translational palmitoylation of ionotropic glutamate receptors in excitatory synaptic functions.离子型谷氨酸受体的翻译后棕榈酰化在兴奋性突触功能中的作用。
Br J Pharmacol. 2021 Feb;178(4):784-797. doi: 10.1111/bph.15050. Epub 2020 Apr 7.
5
Palmitoylation regulates glutamate receptor distributions in postsynaptic densities through control of PSD95 conformation and orientation.棕榈酰化通过控制PSD95的构象和取向来调节突触后致密物中谷氨酸受体的分布。
Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8482-E8491. doi: 10.1073/pnas.1612963113. Epub 2016 Dec 12.
6
Dynamic Regulation of N-Methyl-d-aspartate (NMDA) and α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptors by Posttranslational Modifications.通过翻译后修饰对N-甲基-D-天冬氨酸（NMDA）和α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体的动态调节
J Biol Chem. 2015 Nov 27;290(48):28596-603. doi: 10.1074/jbc.R115.652750. Epub 2015 Oct 9.
7
Synaptic localization of ionotropic glutamate receptors in the rat substantia nigra.离子型谷氨酸受体在大鼠黑质中的突触定位
Neuroscience. 2000;101(4):1037-51. doi: 10.1016/s0306-4522(00)00432-2.
8
Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins.MAGUK支架蛋白介导的谷氨酸受体的突触转运
Trends Cell Biol. 2007 Jul;17(7):343-52. doi: 10.1016/j.tcb.2007.07.005. Epub 2007 Jul 20.
9
Regulation of glutamate receptor trafficking by leptin.瘦素对谷氨酸受体转运的调节。
Biochem Soc Trans. 2009 Dec;37(Pt 6):1364-8. doi: 10.1042/BST0371364.
10
Smarter neuronal signaling complexes from existing components: how regulatory modifications were acquired during animal evolution: evolution of palmitoylation-dependent regulation of AMPA-type ionotropic glutamate receptors.从现有成分中构建更智能的神经元信号复合物：动物进化过程中如何获得调节修饰：棕榈酰化依赖性调节 AMPA 型离子型谷氨酸受体的进化。
Bioessays. 2013 Nov;35(11):929-39. doi: 10.1002/bies.201300076. Epub 2013 Aug 14.
引用本文的文献
1
Palmitoylation of synaptic proteins: roles in functional regulation and pathogenesis of neurodegenerative diseases.蛋白质棕榈酰化：在神经退行性疾病的功能调节和发病机制中的作用。
Cell Mol Biol Lett. 2024 Aug 10;29(1):108. doi: 10.1186/s11658-024-00625-2.
2
Activity-dependent post-translational regulation of palmitoylating and depalmitoylating enzymes in the hippocampus.海马体内依赖于活动的棕榈酰化和去棕榈酰化酶的翻译后调节。
J Cell Sci. 2023 Apr 1;136(7). doi: 10.1242/jcs.260629. Epub 2023 Apr 5.
3
Structure, Function, and Pharmacology of Glutamate Receptor Ion Channels.谷氨酸受体离子通道的结构、功能和药理学。
Pharmacol Rev. 2021 Oct;73(4):298-487. doi: 10.1124/pharmrev.120.000131.
4
A sticky situation: regulation and function of protein palmitoylation with a spotlight on the axon and axon initial segment.棘手的情况：蛋白质棕榈酰化的调节与功能，聚焦于轴突和轴突起始段
Neuronal Signal. 2021 Oct 6;5(4):NS20210005. doi: 10.1042/NS20210005. eCollection 2021 Dec.
5
Roles of palmitoylation in structural long-term synaptic plasticity.棕榈酰化在结构长时程突触可塑性中的作用。
Mol Brain. 2021 Jan 11;14(1):8. doi: 10.1186/s13041-020-00717-y.
6
The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.棕榈酰基转移酶 ZDHHC14 控制轴突起始段 Kv1 家族钾通道的聚集。
Elife. 2020 Nov 13;9:e56058. doi: 10.7554/eLife.56058.
7
Acyl-PEGyl Exchange Gel Shift Assay for Quantitative Determination of Palmitoylation of Brain Membrane Proteins.用于定量测定脑细胞膜蛋白棕榈酰化的酰基-聚乙二醇交换凝胶迁移分析
J Vis Exp. 2020 Mar 29(157). doi: 10.3791/61018.
8
Regulation of NMDA glutamate receptor functions by the GluN2 subunits.NMDA 谷氨酸受体功能的 GluN2 亚基调节。
J Neurochem. 2020 Jul;154(2):121-143. doi: 10.1111/jnc.14970. Epub 2020 Feb 16.
9
Palmitic acid is an intracellular signaling molecule involved in disease development.软脂酸是一种细胞内信号分子，参与疾病的发生发展。
Cell Mol Life Sci. 2019 Jul;76(13):2547-2557. doi: 10.1007/s00018-019-03092-7. Epub 2019 Apr 9.
10
Altered Regulation of Striatal Neuronal -Methyl-D-Aspartate Receptor Trafficking by Palmitoylation in Huntington Disease Mouse Model.亨廷顿病小鼠模型中棕榈酰化对纹状体神经元N-甲基-D-天冬氨酸受体转运的调节异常
Front Synaptic Neurosci. 2019 Feb 21;11:3. doi: 10.3389/fnsyn.2019.00003. eCollection 2019.
本文引用的文献
1
Palmitoylation of A-kinase anchoring protein 79/150 regulates dendritic endosomal targeting and synaptic plasticity mechanisms.棕榈酰化 A-激酶锚定蛋白 79/150 调节树突内体靶向和突触可塑性机制。
J Neurosci. 2012 May 23;32(21):7119-36. doi: 10.1523/JNEUROSCI.0784-12.2012.
2
Palmitoylation by DHHC5/8 targets GRIP1 to dendritic endosomes to regulate AMPA-R trafficking.DHHC5/8 通过棕榈酰化将 GRIP1 靶向到树突状内体，从而调节 AMPA-R 转运。
Neuron. 2012 Feb 9;73(3):482-96. doi: 10.1016/j.neuron.2011.11.021.
3
Regulation of AMPA receptor trafficking and synaptic plasticity.AMPA 受体运输和突触可塑性的调节。
Curr Opin Neurobiol. 2012 Jun;22(3):461-9. doi: 10.1016/j.conb.2011.12.006. Epub 2012 Jan 2.
4
Reversible palmitoylation regulates surface stability of AMPA receptors in the nucleus accumbens in response to cocaine in vivo.可还原棕榈酰化调节可卡因体内作用下伏隔核中 AMPA 受体的表面稳定性。
Biol Psychiatry. 2011 Jun 1;69(11):1035-42. doi: 10.1016/j.biopsych.2010.11.025. Epub 2011 Jan 8.
5
GRIP1 and 2 regulate activity-dependent AMPA receptor recycling via exocyst complex interactions.GRIP1 和 2 通过外泌体复合物相互作用调节活性依赖的 AMPA 受体循环。
Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19038-43. doi: 10.1073/pnas.1013494107. Epub 2010 Oct 18.
6
AMPA receptor signaling through BRAG2 and Arf6 critical for long-term synaptic depression.AMPA 受体通过 BRAG2 和 Arf6 的信号转导对长时程突触抑制至关重要。
Neuron. 2010 Jun 10;66(5):768-80. doi: 10.1016/j.neuron.2010.05.003.
7
TARP phosphorylation regulates synaptic AMPA receptors through lipid bilayers.TARP 磷酸化通过脂双层调节突触 AMPA 受体。
Neuron. 2010 Jun 10;66(5):755-67. doi: 10.1016/j.neuron.2010.04.035.
8
DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory.DHHC5 与突触后密度蛋白-95（PSD-95）的 PDZ 结构域 3 相互作用，在学习和记忆中发挥作用。
J Biol Chem. 2010 Apr 23;285(17):13022-31. doi: 10.1074/jbc.M109.079426. Epub 2010 Feb 22.
9
Protein palmitoylation in neuronal development and synaptic plasticity.蛋白质棕榈酰化在神经元发育和突触可塑性中的作用。
Nat Rev Neurosci. 2010 Mar;11(3):161-75. doi: 10.1038/nrn2788.
10
Regulation of synaptic structure and function by palmitoylated AMPA receptor binding protein.棕榈酰化 AMPA 受体结合蛋白对突触结构和功能的调节。
Mol Cell Neurosci. 2010 Apr;43(4):341-52. doi: 10.1016/j.mcn.2010.01.001. Epub 2010 Jan 18.
Zotero 插件