Shriners Hospital Pediatric Research Center (Center for Neurorehabilitation and Neural Repair), Temple University Medical School, 3500 N. Broad Street, Philadelphia, PA 19130, USA.
Biochem Soc Trans. 2013 Feb 1;41(1):72-8. doi: 10.1042/BST20120223.
In recent years, it has become clear that both AMPA (α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)- and NMDA (N-methyl-D-aspartate)-type glutamate receptors, and many of their interacting partners, are palmitoylated proteins. Interfering with palmitoylation dramatically affects receptor trafficking and distribution and, in turn, can profoundly alter synaptic transmission. Increased knowledge of synaptic palmitoylation not only will aid our understanding of physiological neuronal regulation, but also may provide insights into, and even novel treatments for, neuropathological conditions. In the present paper, we review recent advances regarding the regulation of ionotropic glutamate receptor trafficking and function by palmitoylation.
近年来，人们已经清楚地认识到，AMPA（α-氨基-3-羟基-5-甲基异恶唑-4-丙酸）和 NMDA（N-甲基-D-天冬氨酸）型谷氨酸受体及其许多相互作用的伴侣都是棕榈酰化蛋白。干扰棕榈酰化作用会极大地影响受体的运输和分布，进而可以深刻改变突触传递。增加对突触棕榈酰化的了解不仅将有助于我们理解生理神经元调节，而且还可能为神经病理学状况提供见解，甚至提供新的治疗方法。在本文中，我们回顾了最近关于棕榈酰化调节离子型谷氨酸受体运输和功能的进展。
