Department of Clinical Sciences, Section of Oncology, Lund University, SE-221 85 Lund, Sweden.
Biochem Soc Trans. 2013 Feb 1;41(1):273-6. doi: 10.1042/BST20120248.
Over the last few decades, extensive studies by several groups have introduced the concept of cell-derived secreted extracellular membrane vesicles as carriers of complex molecular information. Owing to their pleiotropic biological effects and involvement in a wide variety of biological processes, extracellular membrane vesicles have been implicated in physiological as well as pathological events, including tumour development and metastasis. In the present review, we discuss the role of secreted membrane vesicles in intercellular communication with a focus on tumour biology. Of particular interest is the potential role of extracellular vesicles as orchestrators of common features of the malignant tumour microenvironment, e.g. coagulation activation and angiogenesis.
在过去几十年中，几个研究小组的广泛研究引入了细胞衍生的分泌细胞外膜囊泡作为复杂分子信息载体的概念。由于其多效性的生物学效应以及参与多种生物学过程，细胞外膜囊泡与生理和病理事件有关，包括肿瘤的发生和转移。在本综述中，我们讨论了分泌膜囊泡在细胞间通讯中的作用，重点是肿瘤生物学。特别有趣的是细胞外囊泡作为恶性肿瘤微环境共同特征的协调者的潜在作用，例如凝血激活和血管生成。
