Research group of Microbiology, Vrije Universiteit Brussel, Pleinlaan 2, B-1050 Brussels, Belgium.
Biochem Soc Trans. 2013 Feb 1;41(1):326-31. doi: 10.1042/BST20120312.
For cellular fitness and survival, gene expression levels need to be regulated in response to a wealth of cellular and environmental signals. TFs (transcription factors) execute a large part of this regulation by interacting with the basal transcription machinery at promoter regions. Archaea are characterized by a simplified eukaryote-like basal transcription machinery and bacteria-type TFs, which convert sequence information into a gene expression output according to cis-regulatory rules. In the present review, we discuss the current state of knowledge about these rules in archaeal systems, ranging from DNA-binding specificities and operator architecture to regulatory mechanisms.
为了保持细胞的健康和生存，基因表达水平需要根据大量的细胞和环境信号进行调节。转录因子（TFs）通过与启动子区域的基本转录机制相互作用，执行了这一调节的很大一部分。古菌的基本转录机制具有简化的真核生物样特征，以及细菌型 TF，它们根据顺式调控规则将序列信息转化为基因表达输出。在本综述中，我们讨论了目前关于古菌系统中这些规则的知识状况，范围从 DNA 结合特异性和操作子结构到调控机制。
