Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey.
Cardiovasc Ther. 2013 Jun;31(3):174-8. doi: 10.1111/1755-5922.12025.
The pathophysiology of cardiac syndrome X (CSX) is still unclear, but most patients with CSX have endothelial dysfunction. It has been shown that adropin uniquely effects the regulation of endothelial function. The purpose of the study was to evaluate the role of adropin in CSX. Eighty-six consecutive cardiac syndrome X-diagnosed patients and 86 age-sex matched healthy subjects were enrolled into the study. Serum adropin levels, nitrite/nitrate levels were measured in each subject. The adropin levels were significantly lower in patients with CSX than healthy subjects (1.7 ± 0.8 ng/mL and 3.4 ± 1.8 ng/mL, respectively; P < 0.001). The BMI values of patients with CSX were significantly higher than control subjects (28.1 ± 2.4 kg/m(2) and 26.0 ± 3.7 kg/m(2) , respectively; P < 0.001). Plasma nitrite/nitrate levels were lower in patients with CSX than control subjects (15.9 ± 1.6 μmol/L vs. 25.4 ± 2.8 μmol/L, respectively; P < 0.001), and they have a significantly positive correlation with plasma adropin levels (r = 0.463, P < 0.001). In the multiple linear regression analysis, nitrite/nitrate levels, BMI, and adropin were found to be independent risk factors for CSX. A ROC curve is used to identify the ability of adropin levels to predict the cardiac syndrome X. The area under the ROC curve was 0.854 for adropin levels (P = 0.0001). The sensitivity and specificity values of adropin levels were 90.7 and 70.9%, respectively (cut-off value 2.73). In conclusion, lower serum adropin levels were associated with CSX. Adropin is an independent risk factor for CSX.
心脏 X 综合征（CSX）的病理生理学仍不清楚，但大多数 CSX 患者存在内皮功能障碍。已经证明，阿屈生源独特地影响内皮功能的调节。本研究的目的是评估阿屈生源在 CSX 中的作用。将 86 例连续的 CSX 诊断患者和 86 例年龄和性别匹配的健康受试者纳入研究。测量每个受试者的血清阿屈生源水平和硝酸盐/亚硝酸盐水平。CSX 患者的阿屈生源水平明显低于健康受试者（分别为 1.7 ± 0.8 ng/mL 和 3.4 ± 1.8 ng/mL；P < 0.001）。CSX 患者的 BMI 值明显高于对照组（分别为 28.1 ± 2.4 kg/m(2) 和 26.0 ± 3.7 kg/m(2)；P < 0.001）。CSX 患者的血浆硝酸盐/亚硝酸盐水平低于对照组（分别为 15.9 ± 1.6 μmol/L 和 25.4 ± 2.8 μmol/L；P < 0.001），且与血浆阿屈生源水平呈显著正相关（r = 0.463，P < 0.001）。在多元线性回归分析中，硝酸盐/亚硝酸盐水平、BMI 和阿屈生源被发现是 CSX 的独立危险因素。ROC 曲线用于确定阿屈生源水平预测 CSX 的能力。阿屈生源水平的 ROC 曲线下面积为 0.854（P = 0.0001）。阿屈生源水平的敏感性和特异性值分别为 90.7%和 70.9%（截断值为 2.73）。总之，较低的血清阿屈生源水平与 CSX 相关。阿屈生源是 CSX 的独立危险因素。
