KIRKLARELI UNİVERSITY MEDICAL FACULTY, DEPARTMENT OF NEUROLOGY.
Emergency Clinic, Bakirkoy Dr. Sadi Konuk Education and Training Hospital, Istanbul, Turkey.
Biomedica. 2022 May 1;42(Sp. 1):55-63. doi: 10.7705/biomedica.5943.
More than half of all worldwide deaths and disabilities were caused by stroke. Large artery atherosclerosis is identified as a high etiological risk factor because it accounts for 20% of ischemic stroke.
To identify the significance of TRAIL and adropin release and the relative changes related to S100B levels, as well as the relationship between these biomarkers and the final infarct core, the clinical outcome, and the presence of large artery atherosclerosis in acute stroke patients.
Over a one-year period, demographic, clinical, and neuroimaging findings of 90 consecutive patients with acute ischemic stroke were evaluated.
The mean age of participants was 69.28 ± 10 and 39 patients were female. The increased level of S100B and the decreased levels of sTRAIL with adropin were significantly associated with moderate to severe neurologic presentation (p=0.0001, p=0.002, p=0.002, respectively). On the control CT, a large infarct core was significantly associated with decreased serum levels of sTRAIL and adropin (p=0.001 and p=0.000, respectively); however, the levels of S100B were not significantly associated with good ASPECTS score (p=0.684). Disability and an unfavorable outcome were significantly related to the decreased level of sTRAIL and adropin (p=0.001 and p=0.000 for THRIVE score>5, respectively). Decreased sTRAIL and adropin levels and an increased S100B level were correlated with the presence of large artery atherosclerotic etiologic factors (p=0.000, p=0.000, p=0.036, respectively).
TRAIL and adropin serum levels were associated with poor clinical outcomes and greater infarcted area in acute ischemic stroke patients.
全球一半以上的死亡和残疾是由中风引起的。大动脉粥样硬化被认为是一个高发病风险因素，因为它占缺血性中风的 20%。
确定 TRAIL 和 adiponectin 释放的意义以及与 S100B 水平相关的相对变化，以及这些生物标志物与急性中风患者的最终梗死核心、临床结局和大动脉粥样硬化的存在之间的关系。
在一年的时间里，评估了 90 名连续急性缺血性中风患者的人口统计学、临床和神经影像学发现。
参与者的平均年龄为 69.28±10 岁，39 名患者为女性。S100B 水平升高和 sTRAIL 与 adiponectin 水平降低与中度至重度神经表现显著相关（p=0.0001，p=0.002，p=0.002）。在对照 CT 上，大梗死核心与血清 sTRAIL 和 adiponectin 水平降低显著相关（p=0.001 和 p=0.000）；然而，S100B 水平与良好 ASPECTS 评分无显著相关性（p=0.684）。残疾和不良结局与 sTRAIL 和 adiponectin 水平降低显著相关（THRIVE 评分>5 时，分别为 p=0.001 和 p=0.000）。sTRAIL 和 adiponectin 水平降低以及 S100B 水平升高与大动脉粥样硬化病因因素的存在相关（p=0.000、p=0.000、p=0.036）。
TRAIL 和 adiponectin 血清水平与急性缺血性中风患者的不良临床结局和更大的梗死面积相关。
