Derbent Aysel Uysal, Simavli Serap Aynur, Kaygusuz Ikbal, Gumus Ilknur Inegol, Yılmaz Saynur, Yildirim Melehat, Uysal Sema
Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
J Matern Fetal Neonatal Med. 2013 Jul;26(11):1112-5. doi: 10.3109/14767058.2013.770462. Epub 2013 Feb 27.
Hepcidin is considered a major regulator of iron metabolism. Despite previous studies showing elevated ferritin and hepcidin levels in type 2 diabetes mellitus (DM), no study has investigated hepcidin levels in pregnant women with gestational DM (GDM).
A case-control study was conducted in 30 cases of GDM, 47 pregnant women with impaired glucose tolerance (IGT) and 72 pregnant women with normal glucose tolerance (control) between April 2009 and July 2011. Serum hepcidin and other iron metabolism parameters were analyzed in all groups.
Serum ferritin and serum iron were significantly elevated in the GDM group compared to controls (p = 0.014, p = 0.018, respectively) and to the IGT group (p = 0.021, p = 0.008, respectively). Hepcidin levels were elevated significantly in the diabetic patients compared to the IGT group (p = 0.011) and controls (p = 0.002). We found no correlation between hepcidin and other iron metabolism parameters (Hb, serum iron and ferritin), whereas positive correlations were found between hepcidin and parameters of glucose metabolism (fasting blood glucose, fasting insulin level and glucose value response to glucose challenge test).
Serum hepcidin concentrations were increased in pregnant women with IGT and GDM and this was not related to inflammation parameters.
铁调素被认为是铁代谢的主要调节因子。尽管先前的研究表明2型糖尿病（DM）患者的铁蛋白和铁调素水平升高，但尚无研究调查妊娠期糖尿病（GDM）孕妇的铁调素水平。
2009年4月至2011年7月，对30例GDM孕妇、47例糖耐量受损（IGT）孕妇和72例糖耐量正常孕妇（对照组）进行了病例对照研究。分析了所有组的血清铁调素和其他铁代谢参数。
与对照组相比，GDM组的血清铁蛋白和血清铁显著升高（分别为p = 0.014，p = 0.018），与IGT组相比也显著升高（分别为p = 0.021，p = 0.008）。与IGT组（p = 0.011）和对照组（p = 0.002）相比，糖尿病患者的铁调素水平显著升高。我们发现铁调素与其他铁代谢参数（血红蛋白、血清铁和铁蛋白）之间无相关性，而铁调素与糖代谢参数（空腹血糖、空腹胰岛素水平和葡萄糖耐量试验的血糖值反应）之间存在正相关。
IGT和GDM孕妇的血清铁调素浓度升高，且这与炎症参数无关。
