Department of Oncology, Tianjin Medical University, Tianjin, China.
Eur J Cell Biol. 2013 Mar;92(3):123-8. doi: 10.1016/j.ejcb.2012.11.004. Epub 2013 Jan 26.
The miRNA-29 family of microRNAs (miRNAs), including miR-29a, miR-29b and miR-29c, was recently reported to be aberrantly expressed in multiple cancers. Increasing evidence shows that the abnormal expression of miR-29 family is associated with tumorigenesis and cancer progression, making miR-29s a well-analyzed group of miRNAs in cancer research. Here, in this review we aim to provide an overview of the role of miR-29 family in the pathophysiologic changes of cancer cells and the epigenetic and immune regulation through the biological function of miR-29s.
miRNA-29 家族 microRNAs（miRNAs），包括 miR-29a、miR-29b 和 miR-29c，最近被报道在多种癌症中异常表达。越来越多的证据表明，miR-29 家族的异常表达与肿瘤发生和癌症进展有关，使 miR-29s 成为癌症研究中分析较为透彻的 miRNA 之一。在这里，我们旨在通过 miR-29s 的生物学功能，综述 miR-29 家族在癌细胞的病理生理变化以及表观遗传和免疫调节中的作用。
