弗氏柠檬酸杆菌携带 blaOXA-181 碳青霉烯酶基因的 IncT 型质粒 pT-OXA-181 的完整序列。
Complete sequence of the IncT-type plasmid pT-OXA-181 carrying the blaOXA-181 carbapenemase gene from Citrobacter freundii.
机构信息
Department of Infectious, Istituto Superiore di Sanità, Rome, Italy.
出版信息
Antimicrob Agents Chemother. 2013 Apr;57(4):1965-7. doi: 10.1128/AAC.01297-12. Epub 2013 Jan 28.
Abstract
The gene encoding the carbapenemase OXA-181 (an OXA-48 variant) was identified from a Citrobacter freundii isolate coproducing NDM-1. The whole sequence of plasmid pT-OXA-181 bearing the blaOXA-181 gene was determined and revealed a 84-kb mobilizable but non-self-conjugative IncT-type plasmid. It totally differs from the 7.6-kb ColE-type and blaOXA-181-bearing plasmid recently identified in a Klebsiella pneumoniae isolate. However, in both plasmids, insertion sequence ISEcp1 might have played a role in acquisition of the blaOXA-181 gene.
摘要
从一株同时产生 NDM-1 的弗氏柠檬酸杆菌分离株中鉴定出了编码碳青霉烯酶 OXA-181（一种 OXA-48 变体）的基因。携带 blaOXA-181 基因的质粒 pT-OXA-181 的整个序列已被确定，揭示了一种 84-kb 可移动但非自我接合的 IncT 型质粒。它与最近在肺炎克雷伯菌分离株中发现的 7.6-kb ColE 型和 blaOXA-181 携带质粒完全不同。然而，在这两种质粒中，插入序列 ISEcp1 可能在 blaOXA-181 基因的获得中发挥了作用。
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