哥伦比亚新生儿病房中产 NDM-1 型肺炎克雷伯菌的爆发。
Outbreak of NDM-1-producing Klebsiella pneumoniae in a neonatal unit in Colombia.
机构信息
Bacterial Molecular Genetics Laboratory, Universidad El Bosque, Bogotá, Colombia.
出版信息
Antimicrob Agents Chemother. 2013 Apr;57(4):1957-60. doi: 10.1128/AAC.01447-12. Epub 2013 Jan 28.
Abstract
Six multiresistant, NDM-1-producing Klebsiella pneumoniae strains were recovered from an outbreak that affected six neonatal patients in a Colombian hospital. Molecular analysis showed that all of the isolates harbored the blaNDM-1, qnrA, and intI1 genes and were clonally related. Multilocus sequence typing showed that the isolates belonged to a new sequence type (ST1043) that was different from the sequence types that had previously been reported. This is the first report of NDM-1-producing isolates in South America.
摘要
六株多药耐药、产 NDM-1 的肺炎克雷伯菌从哥伦比亚一家医院发生的一起暴发疫情中分离得到，该疫情影响了 6 名新生儿患者。分子分析表明，所有分离株均携带 blaNDM-1、qnrA 和 intI1 基因，且具有克隆相关性。多位点序列分型显示，这些分离株属于一种新的序列型（ST1043），与先前报道的序列型不同。这是南美首次报告产 NDM-1 的分离株。
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本文引用的文献
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Clin Microbiol Infect. 2012 Sep;18(9):E362-5. doi: 10.1111/j.1469-0691.2012.03928.x. Epub 2012 Jun 28.
2
Identification of New Delhi metallo-β-lactamase 1 in Acinetobacter lwoffii of food animal origin.鉴定食品动物源洛菲不动杆菌中的新德里金属β-内酰胺酶 1。
PLoS One. 2012;7(5):e37152. doi: 10.1371/journal.pone.0037152. Epub 2012 May 18.
3
Emergence of NDM-1-producing Klebsiella pneumoniae in Guatemala.危地马拉产NDM-1肺炎克雷伯菌的出现。
J Antimicrob Chemother. 2012 Jul;67(7):1795-7. doi: 10.1093/jac/dks101. Epub 2012 Mar 29.
4
Rapid detection of carbapenemase genes by multiplex real-time PCR.多重实时 PCR 快速检测碳青霉烯酶基因。
J Antimicrob Chemother. 2012 Apr;67(4):906-9. doi: 10.1093/jac/dkr563. Epub 2012 Jan 9.
5
The emerging NDM carbapenemases.新出现的 NDM 碳青霉烯酶。
Trends Microbiol. 2011 Dec;19(12):588-95. doi: 10.1016/j.tim.2011.09.005. Epub 2011 Nov 9.
6
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Clin Infect Dis. 2012 Jan 1;54(1):150-1. doi: 10.1093/cid/cir720. Epub 2011 Sep 29.
7
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Antimicrob Agents Chemother. 2011 Nov;55(11):5403-7. doi: 10.1128/AAC.00585-11. Epub 2011 Aug 22.
8
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J Antimicrob Chemother. 2011 Sep;66(9):2002-5. doi: 10.1093/jac/dkr226. Epub 2011 Jun 13.
9
Carbapenem resistance in Klebsiella pneumoniae due to the New Delhi Metallo-β-lactamase.肺炎克雷伯菌中新德里金属β-内酰胺酶导致的碳青霉烯类耐药性。
Clin Infect Dis. 2011 Feb 15;52(4):481-4. doi: 10.1093/cid/ciq178.
10
Global spread of New Delhi metallo-β-lactamase 1.新德里金属β-内酰胺酶1的全球传播
Lancet Infect Dis. 2010 Dec;10(12):832. doi: 10.1016/S1473-3099(10)70279-6.
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