Tokyo and Tokorozawa, Japan From the Clinic of Ichigaya, Ministry of Defense; the Departments of Immunology and Microbiology and Basic Pathology, and the Division of Traumatology, Research Institute, National Defense Medical College; and the Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University.
Plast Reconstr Surg. 2013 Feb;131(2):236-240. doi: 10.1097/PRS.0b013e3182789c79.
The authors evaluated the efficacy of an ultrathin nanosheet consisting of poly-L-lactic acid (75 nm thick) as a wound dressing material. A full-thickness skin defect was made on the backs of mice and overlapped with or without the poly-L-lactic acid nanosheet. Wound healing was more rapidly improved by overlapping with the nanosheet, especially in the early healing period (at 4 to 6 days). The remaining wound area in the treatment group was significantly smaller at 4 days than in the control group. Histologically, a clear layer was observed over the granulation layer by the nanosheet therapy at 4 days. Thus, overlapping therapy with the poly-L-lactic acid nanosheet accelerated wound healing and formed a clear layer just above the granulation tissue. The poly-L-lactic acid nanosheet may have potential as a novel wound dressing to promote wound healing.
作者评估了由聚 L-乳酸（75nm 厚）组成的超薄纳米片作为伤口敷料材料的功效。在小鼠背部制造全层皮肤缺损，并将其与聚 L-乳酸纳米片重叠或不重叠。通过重叠纳米片，伤口愈合得到了更快的改善，特别是在早期愈合期（4 至 6 天）。在治疗组中，第 4 天的剩余伤口面积明显小于对照组。组织学上，在纳米片治疗的第 4 天，肉芽层上观察到一个清晰的层。因此，聚 L-乳酸纳米片的重叠治疗加速了伤口愈合，并在肉芽组织上方形成了一个清晰的层。聚 L-乳酸纳米片可能具有作为一种新型伤口敷料来促进伤口愈合的潜力。
