Jiangsu Institute of Parasitic Diseases, 117 Yangxiang, Meiyuan, Wuxi City, 214064, Jiangsu Province, People's Republic of China.
Parasitol Res. 2013 Mar;112(3):909-15. doi: 10.1007/s00436-013-3303-9. Epub 2013 Jan 29.
Schistosomiasis remains a major public health problem with an estimated 200 million people infected in the world, and in China, schistosomiasis japonica is endemic in the south part of the country. In 1960s, before praziquantel was developed, there were about seven million patients. Praziquantel has a high efficacy against Schistosoma, few and transient side effects, simple administration and competitive cost, and is equally suited for both individual and large-scale treatment. Praziquantel has been widely used in the morbidity control, transmission control, and prevention of schistosomiasis japonica in China since 1980s. The schemes of praziquantel chemotherapy include the diagnostic selective chemotherapy, extensive chemotherapy, mass chemotherapy, stratified chemotherapy, phased chemotherapy, etc. Chemotherapy alone or combined with other control measure, such as Oncomelania snail control, health education, safety water supply, and so on, has achieved a great success, and there are only 0.33 million infected people now. This paper reviews the application of praziquantel in the schistosomiasis japonica control strategies in China so as to provide the rich experiences for reference of health workers of other countries where schistosomiasis is endemic.
血吸虫病仍然是一个主要的公共卫生问题，估计全球有 2 亿人感染，在中国，日本血吸虫病流行于南方地区。在 20 世纪 60 年代，吡喹酮开发之前，大约有 700 万患者。吡喹酮对血吸虫病具有高效、副作用少且短暂、用药简单、价格具有竞争力等特点，非常适合个体和大规模治疗。自 20 世纪 80 年代以来，吡喹酮已广泛应用于中国的血吸虫病发病率控制、传播控制和预防。吡喹酮化疗方案包括诊断性选择性化疗、广泛化疗、大规模化疗、分层化疗、阶段性化疗等。单纯化疗或结合其他控制措施，如钉螺控制、健康教育、安全供水等，已取得巨大成功，目前仅有 0.33 万人感染。本文综述了吡喹酮在中国日本血吸虫病防治策略中的应用，为其他流行地区的卫生工作者提供了丰富的经验。
