c-Met 对预测中国农村人群癌前胃病变进展的价值。
Value of c-Met for Predicting Progression of Precancerous Gastric Lesions in Rural Chinese Population.
机构信息
Department of Pathology, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education).
出版信息
Chin J Cancer Res. 2012 Mar;24(1):18-22. doi: 10.1007/s11670-012-0018-x.
OBJECTIVE
To investigate the value of c-Met in predicting progression of precancerous gastric lesions.
METHODS
A population-based study was conducted to detect the overexpression of c-Met by immunohisto- chemical analysis in 124 subjects with precancerous gastric lesions. Odds ratio (OR) and 95% confidence interval (95% CI) were calculated for the association of c-Met overexpression with the risk of advanced gastric lesions.
RESULTS
The positive rates of c-Met were 55.7% in intestinal metaplasia (IM) and 64.8% in dysplasia (DYS), respectively. Stratified analysis indicated that the proportion of c-Met overexpression was 71.4% for IM progressive group, significantly higher than that for IM persistent group (40.0%, P<0.05). Compared to the IM persistent group, unconditional logistic regression showed that OR of c-Met overexpression for the IM progressive group was 7.416 (95% CI: 2.084-26.398).
CONCLUSION
c-Met plays an important role in gastric carcinogenesis. Detection of c-Met is of value in predicting progression of precancerous gastric lesions from IM to DYS.
目的
探讨 c-Met 在预测癌前胃病变进展中的价值。
方法
采用基于人群的研究，通过免疫组织化学分析检测 124 例癌前胃病变患者 c-Met 的过表达。计算 c-Met 过表达与高级胃病变风险之间的关联的优势比（OR）和 95%置信区间（95%CI）。
结果
肠上皮化生（IM）和发育不良（DYS）中 c-Met 的阳性率分别为 55.7%和 64.8%。分层分析表明，IM 进展组 c-Met 过表达的比例为 71.4%，明显高于 IM 持续组（40.0%，P<0.05）。与 IM 持续组相比，非条件 logistic 回归显示，IM 进展组 c-Met 过表达的 OR 为 7.416（95%CI：2.084-26.398）。
结论
c-Met 在胃癌发生中起重要作用。检测 c-Met 对预测从 IM 到 DYS 的癌前胃病变进展具有价值。
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