Department of Ultrasound In Medicine, Shanghai Jiao tong University Affiliated 6th People's Hospital, Shanghai Institute of Ultrasound In Medicine, Shanghai 200233, China; ; Department of Ultrasound In Medicine, Shandong University Affiliated Qian Fo Shan Hospital, Ji Nan 250014, China.
Chin J Cancer Res. 2012 Dec;24(4):368-73. doi: 10.3978/j.issn.1000-9604.2012.08.03.
Ultrasound can be used not only in the examination, but also in the therapy, especially in the therapy of cancer, which has got effect in the treatment. Sonodynamic therapy is an experimental cancer therapy which uses ultrasound to enhance the cytotoxic effects of drugs known as sonosensitizers. It has been tested in vitro and in vivo. The ultrasound could penetrate the tissue and cell under some of conditions which directly changes the cell membranes permeability, thereby allowing the delivery of exogenous molecules into the cells in some degree. Ultrasound could inhibit the proliferation or induce the apoptosis of the cancer cell in vitro or in vivo. Recent research indicated low frequency and low intensity ultrasound could induce cells apoptosis, and which could be strengthened by sonodynamic sensitivities, microbubbles, chemotherapeutic drugs and so on. Most kinds of ultrasound suppressed the proliferation of cancer cell through inducing the apoptosis of cancer cell. The mechanism of apoptosis is not clear. In this review, we will focus on and discuss the mechanisms of the induction of the apoptosis of cancer cell by ultrasound.
超声不仅可用于检查，还可用于治疗，特别是在癌症治疗方面，已显示出疗效。声动力学疗法是一种实验性的癌症治疗方法，它利用超声增强称为声敏剂的药物的细胞毒性作用。该疗法已在体外和体内进行了测试。在某些条件下，超声可以穿透组织和细胞，直接改变细胞膜的通透性，从而在一定程度上将外源性分子递送到细胞内。超声可以抑制体外或体内癌细胞的增殖或诱导其凋亡。最近的研究表明，低频低强度超声可以诱导细胞凋亡，并且可以通过声动力学敏感性、微泡、化疗药物等增强。大多数类型的超声通过诱导癌细胞凋亡来抑制癌细胞的增殖。其凋亡机制尚不清楚。在这篇综述中，我们将重点讨论并探讨超声诱导癌细胞凋亡的机制。
