Unité de recherche «Eléments trace, radicaux libres, systèmes antioxydants et pathologies humaines», Faculté de médecine de Monastir, Université de Monastir, rue Avicenne, 5019 Monastir, Tunisia.
Nutr J. 2013 Jan 29;12:18. doi: 10.1186/1475-2891-12-18.
The oxidant stress, expected to increase in obese adults, has an important role in the pathogenesis of many diseases. It results when free radical formation is greatly increased or protective antioxidant mechanisms are compromised. The main objective of this study is to evaluate the antioxidant response to obesity-related stress in healthy children.
A hundred and six healthy children (54 obese and 52 controls), aged 6-12 years old, participated in this study. The collected data included anthropometric measures, blood pressure, fasting glucose, total cholesterol, triglycerides and enzymatic antioxidants (Superoxide dismutase: SOD, Catalase: CAT and Glutathione peroxidase: GPx).
The first step antioxidant response, estimated by the SOD activity, was significantly higher in obese children compared with normal-weight controls (p < 0.05). Mean activities of anti-radical GPx and CAT enzymes were not affected by the BMI increase. Although, total cholesterol levels were statistically higher in the obese group, there was no significant association with the SOD activity.
The obesity-related increase of the oxidant stress can be observed even in the childhood period. In addition to the complications of an increased BMI, obesity itself can be considered as an independent risk factor of free radical production resulting in an increased antioxidant response.
氧化应激预计会在肥胖成年人中增加，在许多疾病的发病机制中起着重要作用。当自由基形成大大增加或保护抗氧化机制受损时，就会发生这种情况。本研究的主要目的是评估肥胖相关应激对健康儿童的抗氧化反应。
本研究纳入了 106 名健康儿童（54 名肥胖儿童和 52 名对照组儿童），年龄在 6-12 岁之间。收集的数据包括人体测量指标、血压、空腹血糖、总胆固醇、甘油三酯和酶抗氧化剂（超氧化物歧化酶：SOD、过氧化氢酶：CAT 和谷胱甘肽过氧化物酶：GPx）。
与正常体重对照组相比，肥胖儿童的第一阶段抗氧化反应（通过 SOD 活性估计）显著更高（p<0.05）。抗自由基 GPx 和 CAT 酶的平均活性不受 BMI 增加的影响。尽管肥胖组的总胆固醇水平统计学上较高，但与 SOD 活性没有显著关联。
即使在儿童期，也可以观察到肥胖相关的氧化应激增加。除了 BMI 增加的并发症外，肥胖本身也可以被视为自由基产生增加的独立危险因素，从而导致抗氧化反应增加。
