Department of Chemical Engineering, Tsinghua University, Beijing, China.
Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2013 Jul-Aug;5(4):320-8. doi: 10.1002/wnan.1210. Epub 2013 Jan 29.
Nanotechnology offers immense opportunities for regulating and improving biological functions of proteins in vitro. Recent years have witnessed growing efforts to develop protein-incorporated hybrid nanostructured materials with potential applications in functional materials, enzymatic catalysis, drug delivery, and analytical sciences. In this review, recent advances in functional protein-organic/inorganic hybrid nanomaterials are discussed with an emphasis on the novel preparation methods, resulting nanostructures, and their potential applications in drug delivery and enzymatic catalysis. Future directions toward the rational design of these bionanomaterials are suggested.
纳米技术为体外调节和改善蛋白质的生物功能提供了巨大的机会。近年来，人们越来越努力地开发包含蛋白质的混合纳米结构材料，这些材料具有在功能材料、酶催化、药物输送和分析科学中的潜在应用。本文讨论了功能蛋白-有机/无机杂化纳米材料的最新进展，重点介绍了新的制备方法、所得纳米结构及其在药物输送和酶催化中的潜在应用。本文还对这些生物纳米材料的合理设计提出了未来的方向。
