Rácz Emőke, Prens Errol P
Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Dermatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Adv Exp Med Biol. 2017;996:287-294. doi: 10.1007/978-3-319-56017-5_24.
Phototherapy is an effective treatment modality for several skin diseases which has been in use from the era of the Egyptians. Insight into its mode of action has gradually accumulated over the past decades. A crucial biological effect of ultraviolet radiation is the induction of apoptosis in T lymphocytes and in keratinocytes in the epidermis. Via this mechanism inflammation-induced pathological changes characteristic of psoriasis are counteracted.Phototherapy remains the only therapeutic option for certain patient groups where modification of the systemic immune reactions is contraindicated, such as by HIV, internal malignancy or pregnancy. UVB treatment is highly cost-effective, which is important in this age of increasing health care costs.
光疗是一种治疗多种皮肤病的有效方法，自埃及时代起就已使用。在过去几十年中，人们对其作用方式的认识逐渐积累。紫外线辐射的一个关键生物学效应是诱导表皮中的T淋巴细胞和角质形成细胞凋亡。通过这种机制，可以对抗银屑病特有的炎症诱导的病理变化。对于某些患者群体，如感染艾滋病毒、患有内部恶性肿瘤或怀孕等情况下禁忌改变全身免疫反应的患者，光疗仍然是唯一的治疗选择。UVB治疗具有很高的成本效益，在这个医疗成本不断增加的时代，这一点很重要。
