Bio and Soft Matter (BSMA), Institute of Condensed Matter and Nanosciences (IMCN), Université catholique de Louvain, Place L. Pasteur, 1, Louvain-la-Neuve, Belgium.
Chem Soc Rev. 2013 Sep 7;42(17):7117-29. doi: 10.1039/c3cs35469e. Epub 2013 Jan 30.
Stimuli-responsive block copolymer micelles are the topic of intense research since they are able to show sharp and eventually reversible responses to various environmental changes and find applications in various fields including controlled drug delivery. Among all the available stimuli, light has recently attracted much attention since it can be localized in time and space, and it can also be triggered from outside of the system. In this tutorial review, we highlight the progress realized in recent years. More precisely, we provide some guidelines towards the rational design of photo-responsive block copolymers and we present the different photo-responsive moieties that have been used so far. We also discuss the different types of irreversible and reversible responses encountered by photo-responsive block copolymer micelles. Finally, we suggest possible future developments including the design of biocompatible systems operating at excitation wavelengths compatible for biomedical applications.
刺激响应型嵌段共聚物胶束是目前研究的热点，因为它们能够对各种环境变化表现出明显且最终可恢复的响应，并在包括控制药物释放在内的各个领域得到应用。在所有可用的刺激物中，光最近引起了广泛关注，因为它可以在时间和空间上进行定位，并且可以从系统外部触发。在本教程综述中，我们重点介绍了近年来取得的进展。更确切地说，我们提供了一些关于合理设计光响应嵌段共聚物的指导方针，并介绍了迄今为止使用的不同光响应基团。我们还讨论了光响应嵌段共聚物胶束遇到的不同类型的不可逆和可逆响应。最后，我们提出了可能的未来发展方向，包括设计在与生物医学应用兼容的激发波长下工作的生物相容性系统。
