Quantitative volumetric breast imaging with 3D inverse scatter computed tomography.

A method was developed to map tissue properties of the entire breast including sound speed and attenuation using fully 3D nonlinear inverse-scattering tomography. Clinical measurements suggest that in breast tissue benign and cancerous lesions may be identified in part by these inherent acoustic parameters. Sound speed accuracy and linearity are very high over a wide range (1325-1700 m/sec) with ~1.5 mm resolution at 2 MHz in transmission mode. Attenuation tomograms provide image contrast over a wide range (0-4 dB/cm/MHz) and assist classification of masses. High resolution 0.6 mm volumetric reflection tomograms are acquired with bandwidth 2-8 MHz, are refraction-corrected with the transmission tissue data and are precisely registered in 3D with the transmission volumes. USCT promises an automated whole-breast scan providing a global view of the entire breast in 3D, facilitating comparison to prior exams in a reproducible geometry. Scanner design, automated operation and results of our trial with over 125 subjects with confirmed breast masses will be presented with detailed comparison to conventional sonography and MRI.