QT ultrasound LLC, Novato, USA.
Sci Rep. 2020 Nov 19;10(1):20166. doi: 10.1038/s41598-020-76754-3.
We present here a quantitative ultrasound tomographic method yielding a sub-mm resolution, quantitative 3D representation of tissue characteristics in the presence of high contrast media. This result is a generalization of previous work where high impedance contrast was not present and may provide a clinically and laboratory relevant, relatively inexpensive, high resolution imaging method for imaging in the presence of bone. This allows tumor, muscle, tendon, ligament or cartilage disease monitoring for therapy and general laboratory or clinical settings. The method has proven useful in breast imaging and is generalized here to high-resolution quantitative imaging in the presence of bone. The laboratory data are acquired in ~ 12 min and the reconstruction in ~ 24 min-approximately 200 times faster than previously reported simulations in the literature. Such fast reconstructions with real data require careful calibration, adequate data redundancy from a 2D array of 2048 elements and a paraxial approximation. The imaging results show that tissue surrounding the high impedance region is artifact free and has correct speed of sound at sub-mm resolution.
我们在这里提出了一种定量超声层析成像方法，可在存在高对比介质的情况下提供具有亚毫米分辨率的组织特性的定量 3D 表示。这一结果是对以前工作的推广，以前的工作中不存在高阻抗对比，并且可能为存在骨骼的成像提供一种具有临床和实验室相关性、相对廉价、高分辨率的成像方法。该方法已在乳腺成像中得到验证，并在此推广到存在骨骼的高分辨率定量成像。实验室数据的采集时间约为 12 分钟，重建时间约为 24 分钟——比文献中以前报道的模拟快约 200 倍。如此快速的重建需要仔细的校准，来自 2048 个元素的二维阵列的充分数据冗余以及傍轴近似。成像结果表明，高阻抗区域周围的组织无伪影，并且在亚毫米分辨率下具有正确的声速。
