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[臭氧-氧气疗法在直肠病学中的应用]

[Ozone-oxygen therapy in proctology].

作者信息

Knoch H G, Klug W

出版信息

Ter Arkh. 1990;62(2):93-8.

PMID:2336632
Abstract

The diffusion of oxygen through the colon wall could be demonstrated in animal experiment. The relevant rise in PaO2 can be evidenced both in blood vessels and in the liver, whereby a significantly high increase of 250% above the normal value was recorded in the region of the intestinal wall. The venous blood values were at 230%, those in the portal vein at 134%, and in the liver parenchyma at 127%. When ozone is applied, these values are even higher. An increase can also be recorded in humans by means of transcutaneous PaO2 measurements. In proctology, we view the indication of rectal insufflation to be valid for colitis. The present report covers initial results and experience: a further short report on the possibility of treating hepatitis in the same way will be following.

摘要

在动物实验中可以证明氧气通过结肠壁的扩散。动脉血氧分压(PaO2)的相应升高在血管和肝脏中均得到证实,其中肠壁区域记录到比正常值显著高出250%。静脉血中的数值为230%,门静脉中的数值为134%,肝实质中的数值为127%。当应用臭氧时,这些数值甚至更高。通过经皮测量PaO2,在人体中也可以记录到升高。在直肠病学中,我们认为直肠注入法对结肠炎有效。本报告涵盖了初步结果和经验:随后将有一份关于以同样方式治疗肝炎可能性的进一步简短报告。

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引用本文的文献

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The protective effect of intraperitoneal medical ozone preconditioning and treatment on hepatotoxicity induced by methotrexate.腹腔内医用臭氧预处理和治疗对甲氨蝶呤诱导的肝毒性的保护作用。
Int J Clin Exp Med. 2015 Aug 15;8(8):13303-9. eCollection 2015.
2
Effects of ozone oxidative preconditioning on radiation-induced organ damage in rats.臭氧氧化预处理对大鼠放射性器官损伤的影响。
J Radiat Res. 2013 Jan;54(1):36-44. doi: 10.1093/jrr/rrs073. Epub 2012 Aug 21.
3
The effect of rectal ozone on the portal vein oxygenation and pharmacokinetics of propranolol in liver cirrhosis (a preliminary human study).
直肠臭氧对肝硬化门静脉氧合及普萘洛尔药代动力学的影响(初步人体研究)。
Br J Clin Pharmacol. 2011 Mar;71(3):411-5. doi: 10.1111/j.1365-2125.2010.03851.x.
4
Ozone enema: a model of microscopic colitis in rats.臭氧灌肠:大鼠微观性结肠炎模型
Dig Dis Sci. 2001 Nov;46(11):2515-20. doi: 10.1023/a:1012348525208.