Verrazzo G, Coppola L, Luongo C, Sammartino A, Giunta R, Grassia A, Ragone R, Tirelli A
Department of Gerontology, Geriatry and Metabolic Diseases, Second University of Naples, Italy.
Undersea Hyperb Med. 1995 Mar;22(1):17-22.
For many years, clinical practice has consolidated the use of both hyperbaric oxygen and oxygen-ozone therapy in the treatment of peripheral occlusive arterial disease (POAD). We investigated the influence of these treatments on hemorrheologic parameters that play an important role in the pathogenesis and the clinical course of arteriosclerosis. Two groups of 15 patients suffering from POAD, assigned at random either to a cycle of HBO therapy or O2-O3 therapy, were evaluated for blood viscosity, erythrocyte filterability, hematocrit value, fibrinogen concentration, and thrombin time. The O2-O3 therapy caused a significant increase of erythrocyte filterability and a significant decrease of blood viscosity. By contrast, HBO therapy did not produce any significant change. The increase of lipid peri-oxidation, proved by raised malonyldialdehyde plasma levels, seems a likely mechanism involved in the hemorrheologic effects of O2-O3 therapy.
多年来，临床实践已巩固了高压氧和氧 - 臭氧疗法在治疗外周闭塞性动脉疾病（POAD）中的应用。我们研究了这些治疗方法对血液流变学参数的影响，这些参数在动脉粥样硬化的发病机制和临床病程中起着重要作用。两组各15例POAD患者，随机分配接受一个疗程的高压氧治疗或氧 - 臭氧治疗，评估其血液粘度、红细胞滤过率、血细胞比容值、纤维蛋白原浓度和凝血酶时间。氧 - 臭氧治疗使红细胞滤过率显著增加，血液粘度显著降低。相比之下，高压氧治疗未产生任何显著变化。血浆丙二醛水平升高证明脂质过氧化增加，这似乎是氧 - 臭氧治疗血液流变学效应的一个可能机制。
