Sampson A L, Babadi B, Prerau M J, Mukamel E A, Brown E N, Purdon P L
Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2012;2012:6731-4. doi: 10.1109/EMBC.2012.6347539.
Phase-amplitude modulation is a form of cross frequency coupling where the phase of one frequency influences the amplitude of another higher frequency. It has been observed in neurophysiological recordings during sensory, motor, and cognitive tasks, as well as during general anesthesia. In this paper, we describe a novel beamforming procedure to improve estimation of phase-amplitude modulation. We apply this method to 64-channel EEG data recorded during propofol general anesthesia. The method improves the sensitivity of phase-amplitude analyses, and can be applied to a variety of multi-channel neuroscience data where phase-amplitude modulation is present.
相位-振幅调制是一种交叉频率耦合形式，其中一个频率的相位会影响另一个更高频率的振幅。在感觉、运动和认知任务期间以及全身麻醉期间的神经生理学记录中都观察到了这种现象。在本文中，我们描述了一种新颖的波束形成程序，以改进相位-振幅调制的估计。我们将此方法应用于异丙酚全身麻醉期间记录的64通道脑电图数据。该方法提高了相位-振幅分析的灵敏度，并且可以应用于存在相位-振幅调制的各种多通道神经科学数据。
