Kripke D F, Lavie P, Parker D, Huey L, Deftos L J
J Clin Endocrinol Metab. 1978 Nov;47(5):1021-7. doi: 10.1210/jcem-47-5-1021.
To study dynamic interactions among parathyroid hormone (PTH), plasma calcium, and brain states, seven normal subjects were studied for a total of eight nights in our sleep laboratories. Plasma samples were obtained at 10- to 20-min intervals for PTH and calcium determinations. Electroencephalogram, eye movements, and muscle tone were recorded to determine sleep stages. On each night, several distinct peaks in PTH concentration were seen, which in some cases exceeded the all night mean PTH by as much as 300%. Peaks in plasma PTH were significantly nonrandom and tended to recur about every 100 min. PTH concentration was significantly related to cycles of stages 3 and 4 sleep. Total plasma calcium varied less but was significantly related to cycles of rapid eye movement sleep and to cycles of stage 2 sleep. PTH and calcium were significantly interrelated, especially at high frequencies above 40 cycles/day (1 cycle 36 min). In the 14.4 cycles/day (1 cycle/100 min) frequency range where most PTH and calcium variability was found, however, PTH and calcium were more closely related to sleep stages than to each other. These results suggest that the regulation of PTH and calcium is complex and may involve interactions with neural systems.
为研究甲状旁腺激素（PTH）、血浆钙和脑状态之间的动态相互作用，我们在睡眠实验室对7名正常受试者进行了总共8个夜晚的研究。每隔10至20分钟采集血浆样本，用于测定PTH和钙。记录脑电图、眼球运动和肌张力以确定睡眠阶段。在每个夜晚，都观察到PTH浓度有几个明显的峰值，在某些情况下，这些峰值比整夜的平均PTH高出多达300%。血浆PTH的峰值具有显著的非随机性，并且倾向于每100分钟左右重复出现。PTH浓度与3期和4期睡眠周期显著相关。总血浆钙的变化较小，但与快速眼动睡眠周期和2期睡眠周期显著相关。PTH和钙显著相互关联，尤其是在高于40次/天（1次循环/36分钟）的高频时。然而，在发现大多数PTH和钙变异性的14.4次/天（1次循环/100分钟）频率范围内，PTH和钙与睡眠阶段的关系比它们彼此之间的关系更为密切。这些结果表明，PTH和钙的调节是复杂的，可能涉及与神经系统的相互作用。
