The Hotung Molecular Immunology Unit, Division of Clinical Sciences, St George's, University of London, London, UK.
Vaccine. 2013 Mar 15;31(12):1553-9. doi: 10.1016/j.vaccine.2013.01.025. Epub 2013 Jan 29.
Neutralizing antibodies play an essential part in antiviral immunity and are instrumental in preventing or modulating viral diseases. Polyclonal antibody preparations are increasingly being replaced by highly potent monoclonal antibodies (mAbs). Cocktails of mAbs and bispecific constructs can be used to simultaneously target multiple viral epitopes and to overcome issues of neutralization escape. Advances in antibody engineering have led to a large array of novel mAb formats, while deeper insight into the biology of several viruses and increasing knowledge of their neutralizing epitopes has extended the list of potential targets. In addition, progress in developing inexpensive production platforms will make antiviral mAbs more widely available and affordable.
中和抗体在抗病毒免疫中起着至关重要的作用，对于预防或调节病毒性疾病具有重要意义。多克隆抗体制剂正越来越多地被高效的单克隆抗体（mAb）所取代。mAb 和双特异性构建体的鸡尾酒疗法可用于同时靶向多个病毒表位，并克服中和逃逸的问题。抗体工程的进步导致了大量新型 mAb 结构的出现，而对几种病毒生物学的深入了解和对其中和表位的不断增加的认识，扩展了潜在靶标的清单。此外，在开发廉价生产平台方面的进展将使抗病毒 mAb 更广泛地普及和负担得起。
