Nyakatura Elisabeth K, Soare Alexandra Y, Lai Jonathan R
a Department of Biochemistry , Albert Einstein College of Medicine , Bronx , NY , USA.
Hum Vaccin Immunother. 2017 Apr 3;13(4):836-842. doi: 10.1080/21645515.2016.1251536. Epub 2016 Oct 27.
Bispecific antibody engineering, in which binding specificities toward 2 distinct epitopes are combined into a single molecule, can greatly enhance immunotherapeutic properties of monoclonal antibodies. While the bispecific antibody approach has been applied widely to targets for indications such as cancer and inflammation, the development of such agents for viral immunotherapy is only now emerging. Here, we review recent advances in the development of bispecific antibodies for viral immunotherapy, highlighting promising in vitro and in vivo results.
双特异性抗体工程将针对两种不同表位的结合特异性组合到一个分子中，可极大增强单克隆抗体的免疫治疗特性。虽然双特异性抗体方法已广泛应用于癌症和炎症等适应症的靶点，但此类病毒免疫治疗药物的开发目前才刚刚起步。在此，我们综述双特异性抗体用于病毒免疫治疗开发的最新进展，重点介绍有前景的体外和体内研究结果。
