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一项比较两种不同抗生素方案用于剖宫产预防的随机对照试验。

A randomized controlled trial comparing two different antibiotic regimens for prophylaxis at cesarean section.

作者信息

Kamilya Gourisankar, Seal Subrata Lall, Mukherji Joydev, Roy Himangsu, Bhattacharyya Subir Kumar, Hazra Avijit

机构信息

Department of Obstetrics & Gynaecology, R. G. Kar Medical College, 1, Khudiram Bose Sarani, Kolkata, 700 004 India ; Bb-11/G, Salt Lake, Sector-I, Kolkata, 700 064 West Bengal India.

出版信息

J Obstet Gynaecol India. 2012 Feb;62(1):35-8. doi: 10.1007/s13224-012-0148-6. Epub 2012 Apr 20.

DOI:10.1007/s13224-012-0148-6
PMID:23372287
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3366565/
Abstract

OBJECTIVES

To compare the efficacy of intravenous single dose, less costly cefotaxime and more expensive amoxycillin-clavulanic acid combination for prophylaxis at cesarean section.

METHOD

A double blind randomized controlled trial was undertaken on 760 subjects with two parallel treatment groups. Data were analyzed using Graphpad Instat 3 McIntosh software by Student's t test, Mann-Whitney U test, the Chi-squared test or fisher's exact test.

RESULTS

Comparatively narrow spectrum low cost cefotaxime is as effective as more expensive commonly used amoxicillin-clavulanic acid with no significant difference of infectious morbidity and hospital stay (p = 0.27 and 0.11 in elective and emergency cases respectively).

CONCLUSION

Less costly cefotaxime should be preferred compared to more costly amoxicillin-clavulanic acid combination for prophylaxis at cesarean section.

摘要

目的

比较静脉注射单剂量、成本较低的头孢噻肟与成本较高的阿莫西林-克拉维酸联合用药在剖宫产术中预防性应用的疗效。

方法

对760名受试者进行双盲随机对照试验，分为两个平行治疗组。使用Graphpad Instat 3 McIntosh软件，通过学生t检验、曼-惠特尼U检验、卡方检验或费舍尔精确检验对数据进行分析。

结果

光谱相对较窄、成本较低的头孢噻肟与成本较高的常用阿莫西林-克拉维酸效果相当，在感染发病率和住院时间方面无显著差异（择期和急诊病例中p值分别为0.27和0.11）。

结论

在剖宫产术中预防性应用时，与成本较高的阿莫西林-克拉维酸联合用药相比，成本较低的头孢噻肟更值得选用。

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Comparison of ceftriaxone versus triple drug regimen in the prevention of cesarean section infectious morbidities.头孢曲松与三联药物方案预防剖宫产感染性疾病的比较。
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Timing of prophylactic antibiotic administration in the uninfected laboring gravida: a randomized clinical trial.未感染的临产孕妇预防性使用抗生素的时机：一项随机临床试验。
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Antibiotic prophylaxis at caesarean section.剖宫产术中的抗生素预防
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Antibiotic prophylaxis for cesarean section.剖宫产的抗生素预防
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Impact of antibiotic prophylaxis on wound infection after cesarean section in a situation of expected higher risk.在预期风险较高的情况下，抗生素预防对剖宫产术后伤口感染的影响。
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Prophylactic use of antibiotics for nonlaboring patients undergoing cesarean delivery with intact membranes: a meta-analysis.胎膜完整的非临产剖宫产患者预防性使用抗生素的荟萃分析。
Am J Obstet Gynecol. 2001 Mar;184(4):656-61. doi: 10.1067/mob.2001.111303.
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The routine use of cefazolin in cesarean section.剖宫产术中头孢唑林的常规使用。
Int J Gynaecol Obstet. 2000 May;69(2):107-12. doi: 10.1016/s0020-7292(99)00225-8.
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Incidence of postpartum endomyometritis following single-dose antibiotic prophylaxis with either ampicillin/sulbactam, cefazolin, or cefotetan in high-risk cesarean section patients.在高危剖宫产患者中，使用氨苄西林/舒巴坦、头孢唑林或头孢替坦单剂量抗生素预防产后子宫内膜炎的发生率。
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