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皮肤及黏膜表现:艾滋病病毒/艾滋病的有用临床预测指标

Skin and Mucocutaneous Manifestations: Useful Clinical Predictors of HIV/AIDS.

作者信息

Chopra Shashi, Arora Usha

机构信息

Associate Professor, Department of Microbiology, Punjab Institute of Medical Sciences Jalandhar, , India.

出版信息

J Clin Diagn Res. 2012 Dec;6(10):1695-8. doi: 10.7860/JCDR/2012/4615.2633. Epub 2012 Dec 15.

Abstract

BACKGROUND AND AIMS

The HIV infection is associated with several dermatological conditions which may be the first pointer towards the existence of HIV. These may present with unusual and atypical manifestations in the course of the HIV infection. Keeping this in mind, the seroprevalence of HIV in these persons and the spectrum of the skin and the mucocutaneous lesions in the HIV positive patients was studied.

METHODS

The current prospective study was conducted over a period of 3 years (2006-2008). A total of 604 persons who had any kind of skin and mucocutaneous infections were screened for the HIV infection as per the NACO guidelines after recording their clinical and epidemiological profiles.

RESULTS

Out of the 604 patients who were screened, 90(14.90%) were seropositive for the HIV-I antibodies and none was positive for the HIV-2 antibodies. Seventy three point thirty three percent 73.33 of the seropositive patients were in the age group of 15-40 years, with a male-female ratio of 1:1.05. The heterosexual route was the most common mode of transmission (86.6%).A wide range of infectious and noninfectious lesions were observed. In the HIV seropositive patients, oral candidiasis (32.22%) was the most common infectious disease which was observed, followed by herpes zoster (13.33%), genital warts (7.77%) and genital herpes (6.66%). The most common noninfectious manifestation was seborrhoic dermatitis (8.88%), followed by pruritic papular eruptions (7.77%).

CONCLUSION

As there is a high prevalence of the HIV infection in patients who have skin and mucocutaneous disorders, the doctors, during the investigation of these patients, must have a high level of suspicion for the HIV infection in their mind. An early detection of HIV optimizes the chemoprophylaxis for many opportunistic mucocutaneous disorders.

摘要

背景与目的

HIV感染与多种皮肤病相关,这些皮肤病可能是HIV存在的首个线索。在HIV感染过程中,它们可能呈现出不寻常和非典型的表现。考虑到这一点,我们研究了这些人群中HIV的血清流行率以及HIV阳性患者的皮肤和黏膜病变谱。

方法

本前瞻性研究历时3年(2006 - 2008年)。在记录604例患有任何类型皮肤和黏膜感染患者的临床和流行病学资料后,按照印度国家艾滋病控制组织(NACO)指南对其进行HIV感染筛查。

结果

在筛查的604例患者中,90例(14.90%)HIV - I抗体血清学阳性,无一例HIV - 2抗体阳性。73.33%的血清学阳性患者年龄在15 - 40岁之间,男女比例为1:1.05。异性传播途径是最常见的传播方式(86.6%)。观察到多种感染性和非感染性病变。在HIV血清学阳性患者中,口腔念珠菌病(32.22%)是最常见的感染性疾病,其次是带状疱疹(13.33%)、尖锐湿疣(7.77%)和生殖器疱疹(6.66%)。最常见的非感染性表现是脂溢性皮炎(8.88%),其次是瘙痒性丘疹疹(7.77%)。

结论

由于皮肤和黏膜疾病患者中HIV感染率较高,医生在对这些患者进行检查时,必须高度怀疑其感染HIV。早期发现HIV可优化对许多机会性黏膜疾病的化学预防。

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