Department of Dermatology, Xuan Wu Hospital, Capital Medical University, Beijing, China Department of Dermatology and STD/AIDS clinic, Beijing Di Tan Hospital, Capital Medical University, Beijing, China Department of Infectious Diseases, Guangxi Long Tan Hospital, Liuzhou, China.
J Eur Acad Dermatol Venereol. 2013 Mar;27(3):376-82. doi: 10.1111/j.1468-3083.2011.04429.x. Epub 2012 Jan 3.
Human immunodeficiency virus (HIV) infection and acquired immunodeficiency syndrome (AIDS) are frequently associated with diverse mucocutaneous manifestations. However, few studies of HIV/AIDS-related mucocutaneous manifestations have been reported in China.
To investigate the occurrence of mucocutaneous disorders and their relationship with the degree of immunosuppression in 348 HIV-infected Chinese patients. The influence of highly active antiretroviral therapy (HAART) on the spectrum of mucocutaneous manifestations was also evaluated.
A cross-sectional study was performed on 348 HIV-infected Chinese patients seen at the Guangxi Longtan Hospital from August 2010 to November 2010. Collected information included demographic data, HIV-associated mucocutaneous disorders, CD4 cell count, AIDS-defining illness and antiretroviral therapy.
In this study, 62.9% of all patients had mucocutaneous disorders. The prevalence of mucocutaneous disorders in the patients who had received HAART was lower than in those without HAART (54.05% vs. 88.76%, P < 0.001). The prevalence of mucocutaneous disorders was higher in the patients with CD4 < 200 cells/mm(3) in comparison to those with CD4 ≥ 200 cells/mm(3) (P < 0.05). The most common mucocutaneous disorders were oral candidiasis (28.47%), Penicillium marneffei infection (11.49%), drug eruptions (10.06%) and pruritic papular eruption (PPE 5.75%). Oral candidiasis, P. marneffei infection and PPE were significantly more prevalent in patients with a CD4 cell count below 200 cells/mm(3) , but frequency of drug eruptions was not related to the level of CD4 cell counts. Patients treated with HAART had decreased rates of herpes simplex, oral candidiasis and P. marneffei infection, but increased rates of drug eruptions.
A wide range of mucocutaneous disorders were observed in HIV-infected Chinese patients. Oral candidiasis, P. marneffei infection and PPE may be the signs of advanced HIV infection. HAART had an impact on the spectrum of HIV-associated mucocutaneous disorders.
人类免疫缺陷病毒（HIV）感染和获得性免疫缺陷综合征（AIDS）常伴有多种黏膜皮肤表现。然而，中国关于 HIV/AIDS 相关黏膜皮肤表现的研究甚少。
探讨 348 例 HIV 感染中国患者黏膜皮肤障碍的发生及其与免疫抑制程度的关系。还评估了高效抗逆转录病毒治疗（HAART）对黏膜皮肤表现谱的影响。
对 2010 年 8 月至 2010 年 11 月在广西龙潭医院就诊的 348 例 HIV 感染中国患者进行横断面研究。收集的信息包括人口统计学数据、HIV 相关黏膜皮肤障碍、CD4 细胞计数、艾滋病定义性疾病和抗逆转录病毒治疗。
本研究中，所有患者中有 62.9%存在黏膜皮肤障碍。接受 HAART 的患者黏膜皮肤障碍的患病率低于未接受 HAART 的患者（54.05%比 88.76%，P < 0.001）。CD4<200 个细胞/mm3 的患者黏膜皮肤障碍的患病率高于 CD4≥200 个细胞/mm3 的患者（P < 0.05）。最常见的黏膜皮肤障碍是口腔念珠菌病（28.47%）、马尔尼菲青霉感染（11.49%）、药物反应（10.06%）和瘙痒性丘疹性疹（5.75%）。口腔念珠菌病、马尔尼菲青霉感染和 PPE 在 CD4 细胞计数<200 个细胞/mm3 的患者中更为常见，但药物反应的频率与 CD4 细胞计数无关。接受 HAART 的患者单纯疱疹、口腔念珠菌病和马尔尼菲青霉感染的发生率降低，但药物反应的发生率增加。
在 HIV 感染的中国患者中观察到广泛的黏膜皮肤障碍。口腔念珠菌病、马尔尼菲青霉感染和 PPE 可能是 HIV 感染晚期的标志。HAART 对 HIV 相关黏膜皮肤障碍的谱有影响。
