Heo Jae-Hyeok, Lee Kyoung-Min, Park Tai-Hwan, Ahn Jin-Young, Kim Min-Ky
Department of Neurology, Seoul Medical Center, Seoul, Republic of Korea.
Appl Neuropsychol Adult. 2012;19(2):127-31. doi: 10.1080/09084282.2011.643948.
The Addenbrooke's Cognitive Examination (ACE) is a valid dementia-screening test that is a simple and effective instrument. We aimed to assess the diagnostic accuracy of the Korean version of the ACE (K-ACE) in a Korean population. A total of 115 subjects (50 with Alzheimer's dementia [AD], 26 with mild cognitive impairment [MCI], and 39 controls) who visited the Neurology Outpatient Clinic of Seoul Medical Center were included. The ACE was translated and modified to create the K-ACE. The sensitivity, specificity, area under the curve, reliability, and Verbal-Language/Orientation-Memory ratio were evaluated. The receiver-operating characteristic (ROC) curve was used to determine the optimal cutoff score in screening for dementia. The ROC curves showed the superiority of the K-ACE over the Korean Mini-Mental Status Examination in the diagnosis of AD and MCI. The optimal cutoff of the K-ACE for the identification of AD was 68/69, which had a sensitivity of 90% and a specificity of 84%. The K-ACE is a short, reliable, and valid neuropsychological test battery used to screen for dementia in the Korean elderly.
阿登布鲁克认知检查（ACE）是一种有效的痴呆筛查测试，是一种简单且有效的工具。我们旨在评估韩语版ACE（K-ACE）在韩国人群中的诊断准确性。纳入了总共115名受试者，他们均前往首尔医疗中心神经内科门诊就诊，其中50名患有阿尔茨海默病性痴呆（AD），26名患有轻度认知障碍（MCI），39名作为对照。对ACE进行翻译和修改以创建K-ACE。评估了其敏感性、特异性、曲线下面积、可靠性以及语言/定向记忆比率。采用受试者操作特征（ROC）曲线来确定痴呆筛查中的最佳截断分数。ROC曲线显示，在AD和MCI的诊断中，K-ACE优于韩国简易精神状态检查表。K-ACE用于识别AD的最佳截断值为68/69，其敏感性为90%，特异性为84%。K-ACE是一种简短、可靠且有效的神经心理测试组合，用于筛查韩国老年人中的痴呆。
