维生素 D 在过敏性疾病中的作用：揭示一个复杂问题。

Vitamin D in allergic disease: shedding light on a complex problem.

机构信息

Division of Dermatology, University of California, San Diego, La Jolla, Calif, USA.

出版信息

J Allergy Clin Immunol. 2013 Feb;131(2):324-9. doi: 10.1016/j.jaci.2012.12.1562.

DOI:10.1016/j.jaci.2012.12.1562

Abstract

Vitamin D is unique among nutritional factors because the intake of this special vitamin represents the sum of vitamin D obtained from diet, nutritional supplements, and endogenous production after exposure to sunlight. The current recommended nutritional intake requirements reflect needs based on its established role in calcium absorption and bone health. However, recent studies have revealed that vitamin D has important functions in the immune system and might influence the course of immune-mediated disorders, including atopic dermatitis and asthma. This review discusses the scientific rationale for a role for vitamin D in immune function, gives an update on allergic disease associations with lower vitamin D serum levels, and discusses recent observations relating to vitamin D in immune function.

摘要

维生素 D 是营养因素中较为独特的一种，因为这种特殊维生素的摄入量代表了从饮食、营养补充剂和暴露于阳光后内源性产生的维生素 D 的总和。目前推荐的营养摄入需求反映了基于其在钙吸收和骨骼健康方面的既定作用的需求。然而，最近的研究表明，维生素 D 在免疫系统中具有重要功能，并可能影响免疫介导的疾病的病程，包括特应性皮炎和哮喘。本文讨论了维生素 D 在免疫功能中的作用的科学依据，更新了维生素 D 血清水平与过敏性疾病之间的关联，并讨论了与免疫功能相关的维生素 D 的最新观察结果。