Chen Feng, Yang Enhui, Zhang Yuansi, Zhang Yu
Department of Child Healthcare, Wenzhou People's Hospital, Wenzhou, China.
Department of Traditional Chinese Medicine, Wenzhou Yebo Proctology Hospital, Wenzhou, China.
Arch Med Sci. 2024 Jun 6;21(1):42-50. doi: 10.5114/aoms/189503. eCollection 2025.
This study sought to use the latest Life's Essential 8 scoring tool to obtain information on the relationship between serum vitamin D concentration and adolescent cardiovascular health (CVH).
A total of 1,819 teenagers aged 16-19 were enrolled. Associations between serum vitamin D concentrations and CVH ratings were estimated using multiple linear regression and multinomial logistic regression methods, and the dose-response relationship was examined by restricted cubic spline analysis.
After adjusting for all confounding factors, serum vitamin D concentrations were positively correlated with CVH scores (β = 0.12; 95% CI: 0.09-0.14, < 0.001). Among the sex and race subgroups, the correlation was stronger in male, Mexican American and Non-Hispanic Black participants, with odds ratios (ORs) of 1.05 (95% CI: 1.03-1.07), 1.06 (95% CI: 1.04-1.08), = 0.002), 1.07 (95% CI: 1.03-1.11), 1.09 (95% CI: 1.05-1.14), = 0.01, 1.04 (95% CI: 1.01-1.06), and 1.05 (95% CI: 1.02-1.09), = 0.01, respectively. Serum vitamin D concentrations had a nonlinear relationship with CVH ratings. CVH scores grew with serum vitamin D concentrations up to the inflection point (86 nmol/l) (β = 0.17 (95% CI: 0.135-0.206, < 0.001). When serum vitamin D concentrations exceeded 86 nmol/l, CVH scores were not associated with serum vitamin D concentrations.
The study identified a nonlinear relationship between serum vitamin D levels and CVH in US adolescents aged 16-19, with an inflection point at 86 nmol/l. These findings underscore the importance of vitamin D in adolescent CVH and suggest the need for targeted health strategies, particularly in high-risk groups such as male, Mexican American, and Non-Hispanic Black teenagers.
本研究旨在使用最新的生命基本八大要素评分工具，以获取有关血清维生素D浓度与青少年心血管健康（CVH）之间关系的信息。
共招募了1819名年龄在16 - 19岁的青少年。使用多元线性回归和多项逻辑回归方法估计血清维生素D浓度与CVH评分之间的关联，并通过受限立方样条分析检查剂量反应关系。
在调整所有混杂因素后，血清维生素D浓度与CVH评分呈正相关（β = 0.12；95%置信区间：0.09 - 0.14，P < 0.001）。在性别和种族亚组中，男性、墨西哥裔美国人和非西班牙裔黑人参与者的相关性更强，优势比（OR）分别为1.05（95%置信区间：1.03 - 1.07）、1.06（95%置信区间：1.04 - 1.08），P = 0.002）、1.07（95%置信区间：1.03 - 1.11）、1.09（95%置信区间：1.05 - 1.14），P = 0.01、1.04（95%置信区间：1.01 - 1.06）和1.05（95%置信区间：1.02 - 1.09），P = 0.01。血清维生素D浓度与CVH评分呈非线性关系。CVH评分随着血清维生素D浓度升高至拐点（86 nmol/l）（β = 0.17（95%置信区间：0.135 - 0.206，P < 0.001）。当血清维生素D浓度超过86 nmol/l时，CVH评分与血清维生素D浓度无关。
该研究确定了16 - 19岁美国青少年血清维生素D水平与CVH之间的非线性关系，拐点为86 nmol/l。这些发现强调了维生素D在青少年CVH中的重要性，并表明需要制定有针对性的健康策略，特别是针对男性、墨西哥裔美国人和非西班牙裔黑人青少年等高风险群体。
