Galpin O P, Whitaker C J, Whitaker R, Kassab J Y
Ysbyty Gwynedd Hospital, Bangor.
Br J Cancer. 1990 May;61(5):737-40. doi: 10.1038/bjc.1990.165.
One hundred and one histologically confirmed gastric cancer patients in Gwynedd, North Wales, were matched by sex, age and social class to two hospital inpatients without cancer. Seventy-seven of the gastric cancer cases were also matched, using the same criteria, to a patient with a confirmed cancer of a different site (excluding oesophagus). A questionnaire was used to determine bracken exposure and source of water in childhood. Residential and occupational histories were obtained and the consumption of buttermilk, a potential vector of the bracken carcinogens, was quantified. Comparison of the gastric cancer patients with the non-cancer controls indicated that exposure to bracken in childhood had an increased risk (RR = 2.34, P less than 0.001) compared to no exposure and that length of residence in Gwynedd was associated with increased risk (RR = 2.46 for durations of 61 years and over, P less than 0.01). Consumption of buttermilk in childhood and adulthood was attended by increased risk (RR = 1.61 and 1.86 respectively, the latter being statistically significant, P less than 0.05). Neither the residence effect nor consumption of buttermilk in adulthood remained significant when considered in a multivariate analysis with bracken exposure.
在北威尔士格温内德，101名经组织学确诊的胃癌患者按照性别、年龄和社会阶层与两名非癌症住院患者进行匹配。其中77例胃癌病例还按照相同标准与一名确诊为其他部位癌症（不包括食管癌）的患者进行匹配。通过问卷调查确定童年时期蕨菜接触情况和水源。获取居住和职业史，并对作为蕨菜致癌物潜在载体的酪乳的摄入量进行量化。将胃癌患者与非癌症对照进行比较表明，童年时期接触蕨菜相比于未接触，风险增加（相对风险RR = 2.34，P < 0.001），并且在格温内德的居住时长与风险增加相关（居住61年及以上的相对风险RR = 2.46，P < 0.01）。童年和成年时期食用酪乳均伴随着风险增加（相对风险分别为RR = 1.61和1.86，后者具有统计学意义，P < 0.05）。在与蕨菜接触情况进行多变量分析时，成年时期的居住效应和酪乳消费均不再具有显著性。
