Whitaker C J, Dubiel A J, Galpin O P
Centre for Applied Statistics, School of Mathematics, University College of North Wales, Gwynedd.
Epidemiol Infect. 1993 Aug;111(1):63-70. doi: 10.1017/s0950268800056685.
A correlation between childhood crowding and the later development of gastric cancer has been demonstrated by Barker and colleagues, who proposed that the relationship was the consequence of infection by an organism such as Helicobacter pylori. In order to test this hypothesis the presence of IgG antibodies to H. pylori in sera from blood donors in North Wales has been investigated. During donation sessions, donors answered questions relating to social conditions and domicile in childhood (at age 10 years) and adult life (the preceding 2 years). A stepwise logistic regression analysis of the data demonstrated significant independent relationships between seropositivity and the following factors: sharing a bed in childhood, housing density, locality of birth, adult social class and age.
巴克及其同事已经证明，儿童时期居住环境拥挤与后来患胃癌之间存在关联，他们提出这种关系是由诸如幽门螺杆菌等生物体感染所致。为了验证这一假设，对北威尔士献血者血清中幽门螺杆菌IgG抗体的存在情况进行了调查。在献血过程中，献血者回答了与童年时期（10岁时）和成年生活（前两年）的社会状况及居住情况相关的问题。对数据进行的逐步逻辑回归分析表明，血清阳性与以下因素之间存在显著的独立关系：童年时期同床睡觉、住房密度、出生地、成年社会阶层和年龄。
