Medical Faculty, University Cardiology Clinic, Skopje, Macedonia.
Cardiovasc Diabetol. 2013 Feb 1;12:29. doi: 10.1186/1475-2840-12-29.
Limited studies have suggested that inflammatory biomarkers play a role in the initiation and progression of atherosclerosis in diabetic patients. This study assesses the effect of inflammatory biomarkers: fibrinogen and C-reactive protein (C-RP) on the progression of peripheral arterial disease (PAD) in type 2 diabetic (T2D) patients.
Sixty two patients with T2D and PAD (mean age 60.28 ± 27 years and diabetes duration of 8.58 ± 6.17 years) were enrolled in a cohort prospective study of 36 months. Ankle-brachial index (ABI) was measured in all patients at baseline and after 36 months. Multiple linear regression analysis was used to determine the predictivity of variables for fibrinogen, C-RP, plasma lipid fractions, fasting plasma glucose, Body Mass Index (BMI), duration of diabetes status and the age on changes in ABI value.
Linear regression analysis defined F as a predictor for endpoint value of ABI (β = 0.469, p = 0.007). Value of C-RP determinates change of minimal value of ABI (β = 0.449, p = 0.037) and change of mean ABI per year (β = 0.442, p = 0.025).
Our data indicate that plasma determination of fibrinogen and C-RP might have a clinical implication in defining the process of progression of PAD in T2D population.
有限的研究表明，炎症生物标志物在糖尿病患者动脉粥样硬化的发生和发展中起作用。本研究评估了炎症生物标志物：纤维蛋白原和 C 反应蛋白（C-RP）对 2 型糖尿病（T2D）患者外周动脉疾病（PAD）进展的影响。
62 例 T2D 合并 PAD 患者（平均年龄 60.28±27 岁，糖尿病病程 8.58±6.17 年）纳入了一项为期 36 个月的前瞻性队列研究。所有患者在基线和 36 个月时均测量踝臂指数（ABI）。多元线性回归分析用于确定纤维蛋白原、C-RP、血浆脂质成分、空腹血糖、体重指数（BMI）、糖尿病病程和年龄对 ABI 值变化的预测能力。
线性回归分析将 F 定义为 ABI 终点值的预测因子（β=0.469，p=0.007）。C-RP 值决定了 ABI 最小值的变化（β=0.449，p=0.037）和 ABI 每年的平均变化（β=0.442，p=0.025）。
我们的数据表明，血浆纤维蛋白原和 C-RP 的测定可能对定义 T2D 人群 PAD 进展过程具有临床意义。
