Program in Reproductive and Adult Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892-1109, USA.
Fertil Steril. 2013 May;99(6):1610-4. doi: 10.1016/j.fertnstert.2012.12.053. Epub 2013 Jan 30.
To evaluate the correlation of preretrieval quantitative serum hCG level with oocyte maturity.
Retrospective cohort study.
Military assisted reproductive technology (ART) program.
PATIENT(S): Fresh autologous ART cycles.
INTERVENTION(S): Serum hCG level the day before oocyte retrieval.
MAIN OUTCOME MEASURE(S): Linear regression was used to correlate serum hCG levels and oocyte maturity rates. Normal oocyte maturity was defined as ≥75% and the Wilcoxon rank sum test was used to compare serum hCG levels in patients with normal and low oocyte maturity. Threshold analysis was performed to determine hCG levels that could predict oocyte maturity.
RESULT(S): A total of 468 ART cycles were analyzed. Serum hCG level was not correlated with hCG dose; however, it was negatively correlated with body mass index (BMI). Serum hCG levels did not differ between patients with oocyte maturity of <75% and ≥75%. Serum hCG levels did not correlate with oocyte maturity rates. Receiver operator characteristic and less than efficiency curves failed to demonstrate thresholds at which hCG could predict oocyte maturity.
CONCLUSION(S): Serum hCG levels were not correlated with oocyte maturity. Although a positive hCG was reassuring that mature oocytes would be retrieved for most patients, the specific value was not helpful.
评估取卵前定量血清 hCG 水平与卵母细胞成熟度的相关性。
回顾性队列研究。
军事辅助生殖技术（ART）计划。
新鲜自体 ART 周期。
取卵前一天的血清 hCG 水平。
采用线性回归分析血清 hCG 水平与卵母细胞成熟率的相关性。正常卵母细胞成熟定义为≥75%，采用 Wilcoxon 秩和检验比较正常和低卵母细胞成熟患者的血清 hCG 水平。进行阈值分析以确定可预测卵母细胞成熟的 hCG 水平。
共分析了 468 个 ART 周期。血清 hCG 水平与 hCG 剂量无关，但与体重指数（BMI）呈负相关。卵母细胞成熟度<75%和≥75%的患者之间血清 hCG 水平无差异。血清 hCG 水平与卵母细胞成熟率无相关性。受试者工作特征和低于效率曲线未能证明 hCG 可以预测卵母细胞成熟的阈值。
血清 hCG 水平与卵母细胞成熟度无关。尽管大多数患者的 hCG 呈阳性，表明可以取出成熟的卵母细胞，但具体值并没有帮助。
