Department of Biology, Section of Animal Biology, Faculty of Sciences, University of Patras, GR-26500 Patras, Greece.
Mar Environ Res. 2013 Apr;85:13-20. doi: 10.1016/j.marenvres.2012.12.005. Epub 2013 Jan 17.
The present study investigates the antioxidant and pro-oxidant behavior of tannic acid (TA) in hemocytes of mussel Mytilus galloprovincialis, in the presence or the absence of cadmium (Cd). TA at concentrations up to 20 μM, primarily found to be no toxic (in terms of cell viability, superoxide anions, nitric oxide and lipid peroxidation products currently estimated), significantly diminished the cytotoxic and oxidative effects induced by the metal (50 and/or 100 μM) in all cases. On the other hand, higher concentrations of TA (40 and 60 μM) were toxic, thus enhancing Cd-mediated cytotoxic and oxidative effects. The present study showed TA beneficiary properties in hemocytes of mussels, at least at low concentrations, while TA at concentrations higher than 20 μM could serve as an excellent oxidized substrate, thus enhancing toxic effects either alone or with the presence of micromolar concentrations of non transition metals, such as Cd.
本研究调查了单宁酸（TA）在贻贝血细胞中的抗氧化和促氧化行为，研究了在存在或不存在镉（Cd）的情况下的 TA 的作用。浓度高达 20μM 的 TA 主要被发现没有毒性（就细胞活力、超氧阴离子、一氧化氮和目前估计的脂质过氧化产物而言），在所有情况下都显著减轻了金属（50 和/或 100μM）诱导的细胞毒性和氧化作用。另一方面，较高浓度的 TA（40 和 60μM）是有毒的，从而增强了 Cd 介导的细胞毒性和氧化作用。本研究表明，至少在低浓度下，TA 对贻贝血细胞具有有益的特性，而浓度高于 20μM 的 TA 可以作为一种极好的氧化底物，从而增强单独或与非过渡金属（如 Cd）存在的微摩尔浓度的毒性作用。
