口腔人乳头瘤病毒检测在感染人类免疫缺陷病毒的老年人中。
Oral human papillomavirus detection in older adults who have human immunodeficiency virus infection.
机构信息
Department of Diagnostic Sciences, New Jersey Dental School, University of Medicine and Dentistry of New Jersey, Newark, New Jersey 07103, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Apr;115(4):505-14. doi: 10.1016/j.oooo.2012.11.004. Epub 2013 Jan 31.
OBJECTIVE
To evaluate reproducibility of oral rinse self-collection for human papillomavirus (HPV) detection and investigate associations between oral HPV, oral lesions, immune and sociodemographic factors, we performed a cross-sectional study of older adults with human immunodeficiency virus (HIV) infection.
STUDY DESIGN
We collected oral rinse samples from 52 subjects at 2 different times of day, followed by an oral examination and interview. We identified HPV with the use of polymerase chain reaction platforms optimized for detection of mucosal and cutaneous types.
RESULTS
Eighty-seven percent of individuals had oral HPV, of which 23% had oncogenic alpha, 40% had nononcogenic alpha, and 46% had beta or gamma HPV. Paired oral specimens were concordant in all parameters tested. Significant associations observed for oral HPV with increased HIV viral load, hepatitis C seropositivity, history of sexually transmitted diseases, and lifetime number of sexual partners.
CONCLUSIONS
Oral cavity may be a reservoir of subclinical HPV in older adults who have HIV infection. Understanding natural history, transmission, and potential implications of oral HPV warrants further investigations.
目的
评估口腔冲洗液自我采集用于人乳头瘤病毒（HPV）检测的重现性，并研究口腔 HPV 与口腔病变、免疫和社会人口因素之间的关系，我们对感染人类免疫缺陷病毒（HIV）的老年人进行了一项横断面研究。
研究设计
我们在一天中的 2 个不同时间点从 52 名受试者中收集了口腔冲洗样本，随后进行了口腔检查和访谈。我们使用针对粘膜和皮肤类型检测优化的聚合酶链反应平台来鉴定 HPV。
结果
87%的个体存在口腔 HPV，其中 23%存在致癌 alpha，40%存在非致癌 alpha，46%存在 beta 或 gamma HPV。所有测试参数的配对口腔标本均一致。口腔 HPV 与 HIV 病毒载量升高、丙型肝炎血清阳性、性传播疾病史和终生性伴侣数量呈显著相关。
结论
口腔可能是感染 HIV 的老年人亚临床 HPV 的储库。了解口腔 HPV 的自然史、传播途径和潜在影响需要进一步的研究。
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