Piracicaba Dental School, University of Campinas, UNICAMP, São Paulo, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Apr;115(4):532-40. doi: 10.1016/j.oooo.2012.11.007. Epub 2013 Feb 1.
The aim of this study was to describe the clinicopathological and immunohistochemical features of 19 cases of oral eosinophilic ulcers and discuss the hypothesis that this entity could represent a spectrum of the CD30(+) lymphoproliferative disorder.
Clinical data concerning gender, age, affected site, and clinical presentation of 19 patients were collected and a broad immunohistochemical panel was carried out. Eosinophil distribution in relation to muscular tissue was evaluated using an Aperio ScanScope CS scanner.
The mean age of the patients was 58.6 years, with a male preponderance. A single painful ulcer in the tongue was the most common clinical presentation. There was no predilection of eosinophils for surrounding muscular fibers because this population was equally distributed in areas adjacent to and distant from these structures. The inflammatory infiltrate was mainly formed by cytotoxic T lymphocytes and CD30 expression was not limited to large atypical cells; it also stained small reactive lymphocytes.
Considering the clinical, histopathological, and immunohistochemical characteristics, oral eosinophilic ulcers must be considered a self-limiting reactive condition.
本研究旨在描述 19 例口腔嗜酸性溃疡的临床病理和免疫组织化学特征，并探讨这一实体可能代表 CD30(+)淋巴增生性疾病谱的假说。
收集了 19 例患者的临床资料，包括性别、年龄、发病部位和临床表现，并进行了广泛的免疫组织化学检测。使用 Aperio ScanScope CS 扫描仪评估嗜酸性粒细胞与肌肉组织的分布关系。
患者的平均年龄为 58.6 岁，男性居多。最常见的临床表现为单个疼痛性溃疡位于舌部。嗜酸性粒细胞并不倾向于周围的肌肉纤维，因为这一人群在靠近和远离这些结构的区域中分布均匀。炎症浸润主要由细胞毒性 T 淋巴细胞组成，CD30 的表达不仅局限于大型异型细胞，还染色小反应性淋巴细胞。
考虑到临床、组织病理学和免疫组织化学特征，口腔嗜酸性溃疡必须被视为一种自限性反应性疾病。
