Sugaya Norberto, Martignago Fernanda, Pinto Decio, Migliari Dante
Department of Stomatology, Oral Medicine Division, School of Dentistry, University of São Paulo, São Paulo, SP. Brazil.
Open Dent J. 2018 Jan 29;12:19-23. doi: 10.2174/1874210601812010019. eCollection 2018.
This article describes a case of an Oral Eosinophilic Ulcer (OEU) in an otherwise healthy 31-year-old white woman.
The importance of reporting this case was the presence of recurrent episodes with lesions appearing in different areas of the oral mucosa, a type of manifestation not commonly associated with this disease. A typical manifestation of OEU occurs as a single ulceration that goes into healing after an incisional biopsy, a procedure usually required for a proper diagnosis of the disease. In spite of trauma being suggested as the main culprit of OEU, the exact pathogenesis mechanism of this disease remains controversial.
The pattern of the present case contradicts the usually common course of the disease, as the patient had experienced many recurrent episodes for almost 2.5 years, with the recurrences occurring even after biopsies performed during some of the relapses. Differential diagnosis included recurrent aphthous stomatitis, recurrent intra-oral herpes, autoimmune disease, Crohn's disease and malignancy.
Fortunately, the patient has been free of any recurrences for 1.5 years since the last biopsy was taken at the time she came to our clinic seeking treatment.
本文描述了一名31岁健康白人女性患口腔嗜酸性粒细胞性溃疡（OEU）的病例。
报告该病例的重要性在于出现了复发性发作，病变出现在口腔黏膜的不同部位，这种表现类型通常与该疾病无关。OEU的典型表现为单个溃疡，在切开活检后愈合，切开活检是对该疾病进行正确诊断通常所需的程序。尽管创伤被认为是OEU的主要病因，但该疾病的确切发病机制仍存在争议。
本病例的病程与该疾病通常的常见病程相矛盾，因为该患者在近2.5年的时间里经历了多次复发，甚至在某些复发期间进行活检后仍有复发。鉴别诊断包括复发性阿弗他口炎、复发性口腔疱疹、自身免疫性疾病、克罗恩病和恶性肿瘤。
幸运的是，自患者前来我们诊所寻求治疗时进行最后一次活检以来，1.5年未再复发。
