血清β-痕迹蛋白降低与代谢综合征有关。
Reduced serum beta-trace protein is associated with metabolic syndrome.
机构信息
Division of Clinical Pharmacology and Therapeutics, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
出版信息
Atherosclerosis. 2013 Apr;227(2):404-7. doi: 10.1016/j.atherosclerosis.2013.01.008. Epub 2013 Jan 17.
OBJECTIVES
β-trace protein (BTP), also known as lipocalin-type prostaglandin D2 synthase, has shown to regulate glucose and lipid metabolism in vivo. We sought to study the relationship of serum BTP with diabetes and metabolic syndrome (MetS).
METHODS
Data on 3136 participants aged ≥20 years of the National Health and Nutrition Examination Survey III were examined. Logistic regression was used to assess the association of BTP with diabetes and MetS.
RESULTS
Reduced levels of BTP were associated with diabetes and MetS in age, sex, and race/ethnicity adjusted models. After further multivariable adjustment, BTP levels in quartile 1 remained significantly associated with MetS (odds ratio 2.04 [95% CI 1.14-3.70], Ptrend = 0.003) when compared with quartile 4. Among the five components of MetS, BTP was associated with hypertriglyceridemia (Ptrend < 0.001) but not diabetes (Ptrend = 0.099).
CONCLUSION
MetS is associated with a reduced serum level of BTP.
目的
β-痕迹蛋白（BTP），也称为脂联素型前列腺素 D2 合酶，已被证明可在体内调节葡萄糖和脂质代谢。我们旨在研究血清 BTP 与糖尿病和代谢综合征（MetS）的关系。
方法
对 3136 名年龄≥20 岁的国家健康和营养检查调查 III 参与者的数据进行了检查。使用逻辑回归来评估 BTP 与糖尿病和 MetS 的关联。
结果
在年龄、性别和种族/民族调整模型中，BTP 水平降低与糖尿病和 MetS 相关。在进一步进行多变量调整后，与第 4 四分位相比，第 1 四分位的 BTP 水平仍与 MetS 显著相关（比值比 2.04 [95%CI 1.14-3.70]，Ptrend = 0.003）。在 MetS 的五个组成部分中，BTP 与高甘油三酯血症相关（Ptrend <0.001），但与糖尿病无关（Ptrend = 0.099）。
结论
MetS 与血清 BTP 水平降低有关。
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