Snegireva A E, Shaposhnikova G M, Ignatenko M A, Shevliagin V Ia, Dobrynin Ia V, Nikolaeva T G, Borovskiĭ Iu V, Karabach O S
Biull Eksp Biol Med. 1990 Feb;109(2):178-9.
The influence of new synthesized fluoro-silicium-organic complexes on the virus-induced Rauscher leukosis and cell-transferred MX-11 mouse sarcoma was studied. We also studied the cytotoxic effects of these complexes in vitro in the human CaOv cells. Two complexes from seven studied were cytotoxic for CaOv cells. Five complexes from seven studied diminished the mortality of animals with MX-11 tumors on the 27-th day of observation, but the total life duration of the animals in the experimental group was the same as in controls. One complex from seven studied increased the life duration of mice with MX-11 tumors. No effects were noted in relation to mice virus-induced Rauscher leukosis.
研究了新合成的氟硅有机配合物对病毒诱导的劳斯氏白血病和细胞转移的MX - 11小鼠肉瘤的影响。我们还研究了这些配合物在体外对人CaOv细胞的细胞毒性作用。在所研究的七种配合物中，有两种对CaOv细胞具有细胞毒性。在所研究的七种配合物中，有五种在观察的第27天降低了患有MX - 11肿瘤动物的死亡率，但实验组动物的总生存期与对照组相同。在所研究的七种配合物中，有一种延长了患有MX - 11肿瘤小鼠的生存期。未观察到对小鼠病毒诱导的劳斯氏白血病有影响。
