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[4-甲基尿嘧啶和肌肽对大鼠皮肤伤口愈合的影响]

[Effects of 4-methyluracil and carnosine on healing of skin wounds in rats].

作者信息

Silaeva S A, Guliaeva N V, Khatsernova B Ia, Onufriev M V, Nikolaev A Ia

出版信息

Biull Eksp Biol Med. 1990 Feb;109(2):180-2.

PMID:2337657
Abstract

In experiments in vivo and in vitro the authors studied antioxidative properties of 4-methyluracil and carnosine, their capacity to inhibit sex and accelerate healing of skin wounds. 4-methyluracil and carnosine discover almost the same capacity to decrease in the tissues of the wound and the blood serum in the formation of various intermediate products of free radical oxidation. Data are given on the study of the dynamics of wound healing after a 5-day treatment with equimolar quantities.

摘要

在体内和体外实验中,作者研究了4-甲基尿嘧啶和肌肽的抗氧化特性、它们抑制炎症和加速皮肤伤口愈合的能力。4-甲基尿嘧啶和肌肽在伤口组织和血清中自由基氧化各种中间产物形成过程中,降低自由基的能力几乎相同。文中给出了用等摩尔量进行5天治疗后伤口愈合动态的研究数据。

相似文献

1
[Effects of 4-methyluracil and carnosine on healing of skin wounds in rats].[4-甲基尿嘧啶和肌肽对大鼠皮肤伤口愈合的影响]
Biull Eksp Biol Med. 1990 Feb;109(2):180-2.
2
[Effect of 6-methyluracil on regulatory parameters of lipid peroxidation in thermal burn].[6-甲基尿嘧啶对热烧伤中脂质过氧化调节参数的影响]
Patol Fiziol Eksp Ter. 1995 Jan-Mar(1):40-3.
3
[The effect of carnosine on indicators of free radical lipid oxidation during acute stress in rats].[肌肽对大鼠急性应激期间自由基脂质氧化指标的影响]
Nauchnye Doki Vyss Shkoly Biol Nauki. 1989(8):5-16.
4
The antioxidative properties of carnosine and other drugs.肌肽及其他药物的抗氧化特性。
Biochem Int. 1990;20(6):1097-103.
5
[Carnosine prevents the activation of free-radical lipid oxidation during stress].
Biull Eksp Biol Med. 1989 Feb;107(2):144-7.
6
Realization of spontaneous healing function by carnosine.肌肽实现自发愈合功能。
Methods Find Exp Clin Pharmacol. 1988 Aug;10(8):497-507.
7
Action of carnosine and beta-alanine on wound healing.肌肽和β-丙氨酸对伤口愈合的作用。
Surgery. 1986 Nov;100(5):815-21.
8
[Morphological aspects of dermatotrophic action of methyluracil applied epicutaneously].[经皮应用甲基尿嘧啶的皮肤营养作用的形态学方面]
Morfologiia. 2002;122(5):74-8.
9
[Oxymethyluracil stimulates reparative regeneration of skin in rats].[氧甲基尿嘧啶刺激大鼠皮肤的修复性再生]
Eksp Klin Farmakol. 2004 Sep-Oct;67(5):63-6.
10
[Experimental studies on the use of N-2-M cone (L carnosine) in post-dextraction wounds].[N-2-M锥(L-肌肽)在拔牙后创口应用的实验研究]
Rinsho Shika. 1974 Dec 20(278):42-59.

引用本文的文献

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Cutaneous Wound Healing after Topical Application of Gel Formulation in Rats.大鼠局部应用凝胶制剂后的皮肤伤口愈合
Turk J Pharm Sci. 2017 Apr;14(1):65-74. doi: 10.4274/tjps.41713. Epub 2017 Apr 15.
2
Strychnos pseudoquina modulates the morphological reorganization of the scar tissue of second intention cutaneous wounds in rats.马钱子碱调控大鼠二期愈合皮肤创伤瘢痕组织的形态重构。
PLoS One. 2018 Apr 12;13(4):e0195786. doi: 10.1371/journal.pone.0195786. eCollection 2018.
3
Oxidant and antioxidant events during epidermal growth factor therapy to cutaneous wound healing in rats.
表皮生长因子治疗大鼠皮肤创伤愈合过程中的氧化应激和抗氧化反应。
Int Wound J. 2012 Aug;9(4):362-71. doi: 10.1111/j.1742-481X.2011.00895.x. Epub 2011 Dec 1.
4
Antioxidant status during cutaneous wound healing in immunocompromised rats.免疫受损大鼠皮肤伤口愈合过程中的抗氧化状态。
Mol Cell Biochem. 2002 Dec;241(1-2):1-7. doi: 10.1023/a:1020804916733.