Chasovnikova L V, Formazyuk V E, Sergienko V I, Boldyrev A A, Severin S E
Institute of Physico-Chemical Medicine, Moscow, USSR.
Biochem Int. 1990;20(6):1097-103.
The antioxidative effect of various drugs on lipid peroxidation in rat serum in the presence of FeSO4 was studied. The concentration of TBA-active products decreased in the presence of carnosine and anticataract drugs (Japanese Catalin, Chinese Baineiting and Finnish Catachrom-OFTAN). Vita-iodurol (France) and Quinax (USA) were completely inert. One of feasible mechanisms underlying certain pathologies (cataract, rheumatism, etc.) is the damage of biomembranes by active oxygen species. The potent antioxidative activity of carnosine reflects the high therapeutic value of this compound.
研究了多种药物在硫酸亚铁存在下对大鼠血清脂质过氧化的抗氧化作用。在肌肽和抗白内障药物（日本卡他林、中国白内停和芬兰卡他铬-OFTAN）存在的情况下，硫代巴比妥酸活性产物的浓度降低。法国的维他碘罗尔和美国的奎纳克斯完全没有活性。某些病理状态（白内障、风湿病等）潜在的一种可行机制是活性氧对生物膜的损伤。肌肽强大的抗氧化活性反映了该化合物的高治疗价值。
