Guliaeva N V, Obidin A B, Levshina I P, Filonenko A V, Dupin A M, Boldyrev A A
Nauchnye Doki Vyss Shkoly Biol Nauki. 1989(8):5-16.
The effect of carnosine intraperitoneal injection in rats (in doses 0.2, 2.0 or 20 mg/kg) on the vegetative parameters (arterial blood pressure, Hildebrandt index), the content of free radical oxidation (FRO) products and superoxide dismutase activity in serum and brain homogenates and brain lipid composition under normal condition and after different stress forms have been investigated. The carnosine injection in dose 20 mg/kg preserves and increase in arterial pressure and Hildebrandt index at all steps of stress development. The phase non-unidirectional changes in studied biochemical parameters have been revealed depending on the level of stress development in animals under control. The unidirectional and dose-dependent changes of phospholipid content and the level of brain lipids, decrease of FRO products in tissue and brain cholesterol, the increase of the superoxide dismutase activity of serum and brain homogenates have been found in intact and stressed animals after carnosine injection. A comparison of carnosine pharmacokinetics with concentration dependences of the antioxidative effect under in vitro and in vivo experiments comes to conclusion concerning the carnosine indirect adaptogenic action.
研究了肌肽腹腔注射（剂量为0.2、2.0或20mg/kg）对正常状态及不同应激形式下大鼠的植物性参数（动脉血压、希尔德布兰特指数）、自由基氧化（FRO）产物含量、血清和脑匀浆中的超氧化物歧化酶活性以及脑脂质组成的影响。注射20mg/kg剂量的肌肽在应激发展的各个阶段均能维持并提高动脉血压和希尔德布兰特指数。根据对照动物的应激发展水平，揭示了所研究生化参数的阶段性非单向变化。在完整和应激动物注射肌肽后，发现磷脂含量和脑脂质水平呈单向且剂量依赖性变化，组织和脑胆固醇中的FRO产物减少，血清和脑匀浆中的超氧化物歧化酶活性增加。通过对肌肽药代动力学与体外和体内实验中抗氧化作用浓度依赖性的比较，得出了关于肌肽间接适应原作用的结论。
