Research Department, National Institute of Traumatology and Orthopaedics, Rio de Janeiro, Brazil.
Int J Oral Maxillofac Implants. 2013 Jan-Feb;28(1):35-43. doi: 10.11607/jomi.2867.
To investigate the association between interleukin-6 (IL-6) G174C polymorphism and susceptibility to peri-implant disease (PID) and/or chronic periodontitis (CP), in Brazilian subjects.
A total of 103 Brazilian patients were submitted to peri-implant and periodontal examination. According to their peri-implant characteristics, patients were divided into: group A (healthy, n = 52), group B (peri-implant mucositis, n = 20), and group C (peri-implantitis, n = 31). All patients (n = 103) were also characterized as healthy periodontium patients without CP (HP, n = 60) or CP patients (CP, n = 43). DNA was extracted from buccal cells, and the IL-6 G174C polymorphism was genotyped by polymerase chain reaction-restriction fragment length polymorphism. Differences in the prevalence of genotypes and alleles between healthy and ill patients were analyzed by chi-square test (P < .05), considering PID, CP, and PID+CP.
Results considered the presence of PID and/or CP in all patients. The CC genotype was the least common in all groups. The chi-square test showed no significant correlation between genotypes. However, the odds ratio showed that individuals with GG genotype and allele G were 1.53 and 1.43 times more susceptible to PID, respectively. The risk of presenting CP was increased in patients with GG genotype and allele G 1.35 and 1.24 times, respectively. When both diseases were evaluated together, patients with GG genotypes and allele G were 1.75 and 1.50 times more likely to present PID and CP together. When PID was evaluated without CP, patients with allele G were 2.08 times more susceptible to PID.
The frequency of the genotype IL-6 174GG and allele G was different between healthy and ill groups. Therefore, this genotype may be a common risk factor for both CP and PID in Brazilian populations.
研究白细胞介素-6（IL-6）G174C 多态性与巴西人群种植体周围疾病（PID）和/或慢性牙周炎（CP）易感性的关系。
共纳入 103 名巴西患者进行种植体和牙周检查。根据种植体周围的特点，患者被分为：A 组（健康，n=52）、B 组（种植体周围黏膜炎，n=20）和 C 组（种植体周围炎，n=31）。所有患者（n=103）还分为牙周健康且无 CP（HP，n=60）或 CP 患者（CP，n=43）。从颊黏膜细胞中提取 DNA，采用聚合酶链反应-限制性片段长度多态性方法检测 IL-6 G174C 多态性。通过卡方检验（P<.05）分析基因型和等位基因在健康和患病患者中的分布差异，考虑 PID、CP 和 PID+CP。
结果考虑了所有患者中 PID 和/或 CP 的存在。所有组中 CC 基因型最不常见。卡方检验显示基因型之间无显著相关性。然而，优势比表明 GG 基因型和 G 等位基因个体患 PID 的风险分别增加了 1.53 倍和 1.43 倍。GG 基因型和 G 等位基因个体患 CP 的风险分别增加了 1.35 倍和 1.24 倍。当同时评估两种疾病时，GG 基因型和 G 等位基因个体同时发生 PID 和 CP 的风险分别增加了 1.75 倍和 1.50 倍。当单独评估 PID 而不考虑 CP 时，G 等位基因个体患 PID 的风险增加了 2.08 倍。
健康和患病组之间 IL-6 174GG 基因型和 G 等位基因的频率不同。因此，这种基因型可能是巴西人群 CP 和 PID 的共同危险因素。
