Banu Raza Fathima, Vijayaragavalu Sivakumar, Kandasamy Ruckmani, Krishnaswami Venkateshwaran, Kumar V Anand
Department of Prosthodontics, Faculty of Dental Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India.
Department of Life Sciences, Manipur University, Imphal, Manipur, India.
J Oral Biol Craniofac Res. 2023 Mar-Apr;13(2):84-91. doi: 10.1016/j.jobcr.2022.11.005. Epub 2022 Dec 2.
Crestal bone preservation around the dental implant for aesthetic and functional success is widely researched and documented over a decade. Several etiological factors were put forth for crestal bone loss; of which biofilm plays a major role. Biofilm is formed by the colonization of wide spectra of bacteria inhabited around dental implants. Bacterial adherence affects the regulators of bone growth and an early intervention preserves the peri-implant bone. Primary modes of therapy stated in early literature were either prevention or treatment of infection caused by biofilm. This narrative review overviews the microbiome during different stages of peri-implant health, the mechanism of bone destruction, and the expression of the biomarkers at each stage. Microbial contamination and the associated biomarkers varied depending on the stage of peri-implant infection. The comprehensive review helps in formulating a research plan, both in diagnostics and treatment aspects in improving peri-implant health.
为实现美学和功能成功，围绕牙种植体的嵴顶骨保存已在十多年间得到广泛研究和记录。针对嵴顶骨丧失提出了多种病因因素；其中生物膜起主要作用。生物膜由牙种植体周围广泛存在的细菌定植形成。细菌黏附会影响骨生长调节因子，早期干预可保存种植体周围骨。早期文献中指出的主要治疗方式是预防或治疗由生物膜引起的感染。本叙述性综述概述了种植体周围健康不同阶段的微生物群、骨破坏机制以及各阶段生物标志物的表达。微生物污染及相关生物标志物因种植体周围感染阶段而异。该全面综述有助于在改善种植体周围健康的诊断和治疗方面制定研究计划。
